PMID: 377012Mar 27, 1979Paper

Pathways for repair of DNA damaged by alkylating agent in Escherichia coli

Molecular & General Genetics : MGG
Y Yamamoto, M Sekiguchi

Abstract

A strain with both the polA12 and the alk-1 mutation is only slightly more sensitive to methyl methane sulfonate (MMS) than isogenic strains with only one of the mutations. On the other hand, alk-1 recA1 double mutant is much more sensitive to MMS than are strains carrying either one of alk or recA mutation. It was suggested that the alk and the polA gene products are involved in the same DNA repair process whereas the recA function is independent from the process. The yield of MMS-induced mutation (Arg- (argE) to Arg+ reversion) in alk mutant is considerably higher than that in wild type strain. Thus, the repair process in which the alk gene product is involved is relatively accurate. When MMS-treated lambda phages were plated on MMS-treated bacteria, there were considerable increases in survival of treated phage even in recA alk double mutant. It seems that a new repair pathway, which is specific for alkylating agent-induced damages and is not dependent on the RecA function, may be induced on exposure of bacteria to the alkylating agent.

References

May 19, 1977·Nature·L Samson, J Cairns
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E Seeberg
Jul 1, 1978·Journal of Bacteriology·Y YamamotoN Otsuji
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R C TaitD W Smith
May 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·B Low
Jan 1, 1968·Annual Review of Biochemistry·P Howard-Flanders
Oct 1, 1969·Journal of Bacteriology·N S Willetts, A J Clark

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Citations

Jan 1, 1984·Molecular & General Genetics : MGG·N D ClarkeE Seeberg
Jan 1, 1985·Molecular & General Genetics : MGG·H Kataoka, M Sekiguchi
Jul 1, 1985·Mutation Research·N J Sargentini, K C Smith
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J G McCarthyP F Schendel
Jun 1, 1996·Annual Review of Plant Physiology and Plant Molecular Biology·Anne B. Britt
May 1, 1994·Mutation Research·T ItoM Sekiguchi
Mar 1, 1981·Critical Reviews in Toxicology·P F Schendel
Jan 1, 1988·Environmental and Molecular Mutagenesis·M R Volkert
Jan 1, 1991·Mutation Research·K TakanoM Sekiguchi
Sep 1, 1985·Mutation Research·Y NakabeppuM Sekiguchi
Jun 15, 1980·Journal of Molecular Biology·P KarranE Seeberg
Mar 1, 1985·Biochimie·M Defais

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