PMID: 7546377Apr 1, 1995Paper

Pathways from hematopoietic stem cells to thymocytes

Current Opinion in Immunology
H R Rodewald

Abstract

A long-standing debate has been whether commitment to the T cell lineage occurs exclusively following thymus colonization, or whether prethymic T lineage restricted progenitors exist. Recently, the analysis of murine fetal blood for the presence of hematopoietic progenitor cells has led to the identification of a T lineage committed precursor population (designated prothymocytes). Fetal blood prothymocytes lack multipotent progenitor potential as shown by the fact that they fail to reconstitute B lymphocyte, myeloid and erythroid lineages. In addition to prothymocytes, fetal blood also contains a phenotypically distinct, pluripotent progenitor population which can reconstitute both T and B lymphocytes as well as myeloid and erythroid lineages. The identification of a circulating, T lineage restricted precursor population, which is also found in the blood of fetal athymic mice, provides strong evidence that T lineage commitment can precede thymus colonization. The thymus is not, however, exclusively colonized by prothymocytes. Under appropriate developmental conditions, multipotent precursor activity for non-T lineages such as B lymphocytes and thymic dendritic cells can be revealed within the intrathymic precursor pool. Moreove...Continue Reading

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Ikuta, I L Weissman
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K E BurgessC E Rudd
Oct 1, 1992·Immunology Today·L L LanierJ H Phillips
Apr 1, 1992·The Journal of Experimental Medicine·J R FreyJ Sprent
Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Dec 1, 1991·The Journal of Experimental Medicine·L WuK Shortman
Jul 1, 1991·The Journal of Experimental Medicine·M OgawaS Nishikawa
Sep 20, 1991·Cell·A Rolink, F Melchers
Nov 1, 1991·Science·R KühnW Müller
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B CapelB Mintz
Jul 1, 1989·The Journal of Experimental Medicine·T SudoS Nishikawa
Sep 1, 1985·The Journal of Experimental Medicine·B J FowlkesT M Chused
Jul 1, 1988·Science·G J SpangrudeI L Weissman
Oct 1, 1980·European Journal of Immunology·F Melchers, J Abramczuk
Aug 1, 1994·The Journal of Experimental Medicine·M J SánchezJ H Phillips
Oct 1, 1993·The Journal of Experimental Medicine·Y MatsuzakiH Nakauchi
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·J P DiSantoK Rajewsky
Dec 1, 1993·Immunology Today·M Groettrup, H von Boehmer
Nov 1, 1994·The Journal of Experimental Medicine·J J PeschonB L Davison
Nov 18, 1994·Science·C Saint-RufH von Boehmer
Jul 1, 1994·The Journal of Experimental Medicine·T NakaraiJ Ritz
Apr 1, 1994·Current Opinion in Immunology·E J Jenkinson, G Anderson
Apr 1, 1993·Current Opinion in Immunology·N UchidaI L Weissman

❮ Previous
Next ❯

Citations

Feb 1, 1996·Molecular Aspects of Medicine·D J McConkeyS Orrenius
Oct 27, 2007·Cellular Immunology·Hillary H NorrisRobert Chervenak
Aug 13, 1998·Developmental and Comparative Immunology·N S Trede, L I Zon
Aug 13, 1998·Developmental and Comparative Immunology·H R Rodewald, C Haller
Apr 1, 1996·Current Opinion in Immunology·J C Zúñiga-Pflücker, M J Lenardo
Apr 1, 1997·Current Opinion in Immunology·H J Fehling, H von Boehmer
May 29, 1998·Current Opinion in Immunology·H Clevers, P Ferrier
Mar 19, 2002·Scandinavian Journal of Immunology·K PeterssonF Ivars
Mar 6, 2010·International Immunology·T Kent TeagueC Justin Van De Wiele
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·T ReyaR Grosschedl
Dec 16, 1998·Immunological Reviews·J R Carlyle, J C Zúñiga-Pflücker
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·S Dejbakhsh-JonesS Strober
Jan 1, 2014·Research in Veterinary Science·In Su CheonCheol-Heui Yun
Sep 5, 1998·Immunity·J R Carlyle, J C Zúñiga-Pflücker
Aug 1, 1995·Current Biology : CB·R Boismenu, W L Havran
Jul 17, 2010·Trends in Immunology·Susan M Schlenner, Hans-Reimer Rodewald
Mar 23, 2010·Immunity·Susan M SchlennerHans-Reimer Rodewald
Jul 21, 1998·Leukemia & Lymphoma·F Offner, J Plum
Jul 21, 1997·The Journal of Experimental Medicine·J R CarlyleJ C Zúñiga-Pflücker
Mar 27, 2001·European Journal of Immunology·F J StaalH Clevers
Jan 1, 1997·International Reviews of Immunology·J F KearneyF Shu
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Faiza RharbaouiCarlos A Guzmán
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Justin Van De WieleT Kent Teague
Nov 28, 2000·European Journal of Immunology·C C Bleul, T Boehm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.