Patient- and health care-related factors associated with initiation of potentially inappropriate medication in community-dwelling older persons

Basic & Clinical Pharmacology & Toxicology
Virva HyttinenHannu Valtonen

Abstract

Potentially inappropriate medications (PIMs) in older persons are defined as medications of which the potential harms outweigh their benefits. The purpose of this study was to determine how initiation of PIMs accumulate in community-dwelling persons aged 65-74 and ≥75 years, and which patient- and health care-related factors are associated with PIM initiation over time. Data of this study were gathered from population-based registers by a 10% random sample of persons (n = 28 497) aged ≥65 years with no prior PIMs within a 2-year period preceding the index date (1 January 2002), and the study individuals were followed until 2013. The Finnish Prescription Register was linked using a personal identity code to register on inpatient care and causes of deaths and socio-economic data. In this study, 10 698 (37.5%) persons initiated PIMs during the study period. Female gender was associated with PIM initiation in 65-74-year-olds, but not in ≥75-year-olds. In 65-74-year-olds, the risk of PIM initiation increased with the higher income, whereas in ≥75-year-olds, the association between PIM initiation and the high income was not significant. The prescribing physician explained 9%-16% of the variation in the probability of PIM initiation. ...Continue Reading

References

Feb 11, 2004·Archives of Internal Medicine·Margie Rauch Goulding
Apr 29, 2008·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Michael B RothbergPeter K Lindenauer
Oct 2, 2009·Pharmacoepidemiology and Drug Safety·Bienvenu BongueNabil Maarouf
Dec 8, 2009·Basic & Clinical Pharmacology & Toxicology·Kari FuruHenrik Toft Sørensen
May 13, 2010·The Annals of Pharmacotherapy·Brian C LundPeter J Kaboli
Jul 30, 2011·Journal of the American Geriatrics Society·Maarit S DimitrowSaija N S Leikola
May 15, 2012·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Leena K Saastamoinen, Jouko Verho
Aug 15, 2012·European Journal of Clinical Pharmacology·J Simon BellSirpa Hartikainen
Mar 16, 2013·Pharmacoepidemiology and Drug Safety·Holly M HolmesJames S Goodwin
Mar 28, 2013·Geriatrics & Gerontology International·Prasad S NishtalaJune M Tordoff
Apr 3, 2014·BMC Family Practice·Caitriona CahirKathleen Bennett
Oct 22, 2014·BMC Health Services Research·Ágnes Lublóy
Mar 3, 2015·Pharmacoepidemiology and Drug Safety·Leena K Saastamoinen, Jouko Verho
Apr 19, 2015·BMC Geriatrics·Antonio San-JoséUNKNOWN Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators’ project
Sep 27, 2015·European Journal of Clinical Pharmacology·Eline TommeleinKoen Boussery
Oct 9, 2015·Journal of the American Geriatrics Society·UNKNOWN By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel
Mar 17, 2016·International Journal of Health Services : Planning, Administration, Evaluation·Jenni Blomgren
Apr 23, 2016·Journal of the American Geriatrics Society·Marcela JirónTil Stürmer
Jul 28, 2016·BMC Family Practice·Karen VoigtAntje Bergmann
Oct 1, 2016·Health Services Research·G Edward MillerDonna M Fick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Geriatrics Society
Emily FinlaysonAndrew D Auerbach
European Journal of Clinical Pharmacology
Branislava PopovićVera Vlahović-Palčevski
© 2022 Meta ULC. All rights reserved