Patient and physician preferences for oral pharmacotherapy for overactive bladder: two discrete choice experiments

Current Medical Research and Opinion
M HeisenE A Stolk

Abstract

We examined patient and treating physician (general practitioners, urologists, and [uro]gynecologists) preferences for oral pharmacotherapy (antimuscarinics and beta-3 adrenoceptor agonists) for overactive bladder to gain a deeper understanding of which attributes drive their treatment decision-making and to quantify to what extent. Two separate discrete choice experiments were developed and validated using the input of patients and physicians. The patient experiment contained the following attributes: micturition frequency, incontinence, nocturia, urgency, dry mouth, constipation, increased heart rate, and increased blood pressure. The physician experiment contained two additional attributes: coping and atrial fibrillation. Both were fielded in five European countries. To allow for preference heterogeneity, utility functions were estimated using a mixed multinomial logit model. A total of 442 patient and 318 physician responses were analyzed. Patients ranked the attributes based on their largest potential impact on treatment value as follows: incontinence, nocturia, risk of an increased heart rate, urgency, frequency, risk of increased blood pressure, risk of constipation, and risk of dry mouth; and physicians as follows: inco...Continue Reading

References

Jun 2, 2000·BMJ : British Medical Journal·M Ryan, S Farrar
Aug 9, 2001·Annals of Medicine·R Rabin, F de Charro
Sep 11, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K CoyneP Abrams
Feb 1, 2003·Urology·Paul AbramsUNKNOWN Standardisation Sub-Committee of the International Continence Society
Jun 18, 2003·World Journal of Urology·W F StewartA J Wein
Nov 17, 2005·BJU International·Yukio HommaUNKNOWN Neurogenic Bladder Society Committee
Nov 11, 2006·Neurourology and Urodynamics·Martin C MichelMartin Burkart
Dec 17, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Tracey YoungKarin Coyne
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·John F P BridgesJosephine Mauskopf
Mar 29, 2012·Female Pelvic Medicine & Reconstructive Surgery·Jennifer M WuMiriam Kuppermann
Oct 27, 2012·The Journal of Urology·E Ann GormleyUNKNOWN Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction
Jan 23, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·F Reed JohnsonJohn F P Bridges
Jan 28, 2015·The Journal of Urology·E Ann GormleyUNKNOWN Society of Urodynamics, Female Pelvic Medicine

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