Patient and product factors affecting platelet transfusion results

Transfusion
Dominik HeimAlois Gratwohl

Abstract

Providing patients with platelet (PLT) transfusions requires important logistic resources and represents a considerable cost factor. Optimizing PLT transfusions is in the interest of not only patient safety but also economic importance. Only few studies have evaluated factors associated with transfusion results. In a prospective single-center study, 9923 mainly prophylactic PLT transfusions given to 672 patients treated for hematologic malignancies between 1997 and 2004 were investigated. Patient and product factors were analyzed. Transfusion efficacy was measured by the corrected count increment (CCI), and side effects were recorded. The mean CCI of all transfusions was 14.05 (standard deviation, 9.5). The CCI correlates with the transfusion interval. PLT transfusions that resulted in a transfusion interval of 1 day or less had significantly lower CCI of 11.3 than transfusions that resulted in a transfusion interval of 2 days or more (15.57). Allogeneic stem cell transplant recipients had a significantly lower transfusion efficacy (CCI mean, 13.3) whereas patients treated with antithymocyte globulin (ATG) had better CCIs (17.2) compared to patients who were treated with chemotherapy only. Longer PLT storage time and ABO mismat...Continue Reading

References

Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A SchifferUNKNOWN American Society of Clinical Oncology
Jun 26, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Dec 25, 2003·Transfusion·James P AuBuchonScott Murphy
Jul 22, 2004·Transfusion·R J CookUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society for Blood Transfusion

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Citations

Mar 16, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·M J Dijkstra-TiekstraJ de Wildt-Eggen
Mar 17, 2010·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Seth Eisenberg
Aug 16, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Laura InfantiAndreas Buser
May 16, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·G AndreuG Semana
Nov 12, 2009·Transfusion·Nadine ShehataKumanan Wilson
Mar 5, 2013·Transfusion·Martin SternAndreas Buser
Aug 6, 2018·Critical Care : the Official Journal of the Critical Care Forum·Cécile AubronZoe McQuilten
Mar 15, 2018·Frontiers in Medicine·Caroline SutFabrice Cognasse
Aug 20, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M LikerB G Ćepulić
Sep 17, 2021·British Journal of Haematology·Cecilia KarlströmPetter Höglund

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