PMID: 11925295Apr 2, 2002Paper

Patient and psychiatrist ratings of hypothetical schizophrenia research protocols: assessment of harm potential and factors influencing participation decisions

The American Journal of Psychiatry
Laura Weiss RobertsConstantine Lyketsos

Abstract

A central ethical issue in schizophrenia research is whether participants are able to provide informed consent, particularly for protocols entailing medication washouts or placebo treatments. Few data show how patients with schizophrenia and psychiatrists assess such scientific designs regarding potential harm, willingness to participate, and the relative influence of clinicians, family members, and financial incentives upon participation decisions. In this preliminary study, structured interviews were conducted with schizophrenia patients (N=59), and parallel surveys were completed by attending and resident psychiatrists (N=70). Four hypothetical research protocols were rated. Patients were asked about their own views; psychiatrists provided both their personal views and predictions of patient views. Patients and psychiatrists both perceived substantially different levels of harm across the four protocols, identifying significantly greater harm for medication washouts or placebo treatments. Participants were less willing to enroll in protocols perceived as more harmful. Schizophrenia patients found enrollment decisions relatively easy. Patients and psychiatrists indicated that doctor recommendations, monetary incentives, and, ...Continue Reading

Citations

Feb 2, 2010·Social Psychiatry and Psychiatric Epidemiology·Ingo SchäferDieter Naber
Jan 24, 2006·Community Mental Health Journal·Jared R Adams, Robert E Drake
Aug 2, 2006·Current Psychiatry Reports·Kimberly K MathosVishwajit Nimgaonkar
Jul 16, 2003·Psychiatry Research·George E JaskiwMilton E Strauss
Feb 27, 2004·Schizophrenia Research·Laura Weiss RobertsMelinda K Rogers
Jan 1, 2011·AJOB Primary Research·James DuboisWhitney B Hadley
Sep 24, 2005·Schizophrenia Bulletin·Laura B DunnMonique Keehan
Oct 29, 2005·Schizophrenia Bulletin·Philip J CandilisPaul S Appelbaum
Apr 28, 2006·Current Opinion in Psychiatry·Laura B Dunn, Laura Weiss Roberts
May 25, 2013·Academic Medicine : Journal of the Association of American Medical Colleges·James M DuBoisErin Bakanas
Oct 8, 2009·Current Opinion in Psychiatry·Georg Northoff
Nov 1, 2007·Journal of Medical Ethics·K K Anderson, S D Mukherjee
Mar 3, 2009·Psychiatric Services : a Journal of the American Psychiatric Association·Philip T YanosCarolyn S Greene
Oct 19, 2013·American Journal of Public Health·Katherine E McDonald, Dora M Raymaker
Feb 22, 2012·Perspectives in Clinical Research·Umesh Chandra Gupta, Saifuddin Kharawala
Apr 7, 2010·Psychiatry Research·Monika EdlingerW Wolfgang Fleischhacker
Feb 4, 2010·Psychiatry Research·Paul N PfeifferKara Zivin
Jun 3, 2009·The Psychiatric Clinics of North America·Laura B Dunn, Sahana Misra
Aug 3, 2006·Behavioral Sciences & the Law·Laura B Dunn
Jul 29, 2008·Bipolar Disorders·Sahana MisraLinda Ganzini
Sep 18, 2002·The Psychiatric Clinics of North America·Laura Weiss Roberts
Jan 13, 2015·BMC Medical Ethics·Tapani KeränenAnna-Maija Pietilä
Nov 25, 2014·AJOB Empirical Bioethics·Cynthia GeppertKenneth Fletcher
Jan 18, 2017·American Journal on Intellectual and Developmental Disabilities·Katherine E McDonaldThe Project Ethics Expert Panel
Jun 17, 2016·Journal of Empirical Research on Human Research Ethics : JERHRE·Katherine E McDonaldRobert S Olick
Mar 15, 2015·Journal of Empirical Research on Human Research Ethics : JERHRE·Katherine E McDonaldRobert S Olick
Jul 27, 2018·Journal of Empirical Research on Human Research Ethics : JERHRE·Inés Morán-SánchezMaría D Pérez-Cárceles
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Ingo SchäferDieter Naber
Jul 27, 2006·Epidemiologia e psichiatria sociale·Monica PaccaloniChrista Zimmermann
Sep 16, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Daniele ZullinoCharles Bonsack
Apr 6, 2006·The Annals of Pharmacotherapy·Peter F J Schulte

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