Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020.

Journal of Clinical Medicine
Thomas Theo BrehmJulian Schulze Zur Wiesch

Abstract

In this study, we directly compared coronavirus disease 2019 (COVID-19) patients hospitalized during the first (27 February-28 July 2020) and second (29 July-31 December 2020) wave of the pandemic at a large tertiary center in northern Germany. Patients who presented during the first (n = 174) and second (n = 331) wave did not differ in age (median [IQR], 59 years [46, 71] vs. 58 years [42, 73]; p = 0.82) or age-adjusted Charlson Comorbidity Index (median [IQR], 2 [1, 4] vs. 2 [0, 4]; p = 0.50). During the second wave, a higher proportion of patients were treated as outpatients (11% [n = 20] vs. 20% [n = 67]), fewer patients were admitted to the intensive care unit (43% [n = 75] vs. 29% [n = 96]), and duration of hospitalization was significantly shorter (median days [IQR], 14 [8, 34] vs. 11 [5, 19]; p < 0.001). However, in-hospital mortality was high throughout the pandemic and did not differ between the two periods (16% [n = 27] vs. 16% [n = 54]; p = 0.89). While novel treatment strategies and increased knowledge about the clinical management of COVID-19 may have resulted in a less severe disease course in some patients, in-hospital mortality remained unaltered at a high level. These findings highlight the unabated need for e...Continue Reading

References

Feb 1, 2020·The New England Journal of Medicine·Camilla RotheMichael Hoelscher
Mar 12, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Susanne PfefferleMarc Lütgehetmann
Mar 18, 2020·The New England Journal of Medicine·Neeltje van DoremalenVincent J Munster
Mar 24, 2020·JAMA : the Journal of the American Medical Association·Graziano OnderSilvio Brusaferro
May 11, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Dominik NörzMarc Lütgehetmann
May 24, 2020·The New England Journal of Medicine·John H BeigelUNKNOWN ACTT-1 Study Group Members
Jul 18, 2020·The New England Journal of Medicine·UNKNOWN RECOVERY Collaborative GroupMartin J Landray
Aug 22, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Irit NachtigallJulius Dengler
Oct 3, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Susanne PfefferleNicole Fischer
Oct 9, 2020·The New England Journal of Medicine·UNKNOWN RECOVERY Collaborative GroupMartin J Landray
Nov 5, 2020·Scientific Reports·Gabriele SorciSerge Morand
Dec 1, 2020·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Kevin RoedlStefan Kluge
Dec 3, 2020·The New England Journal of Medicine·UNKNOWN WHO Solidarity Trial ConsortiumSoumya Swaminathan
Dec 7, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marion LudwigJochen Walker
Dec 18, 2020·The New England Journal of Medicine·Carlos SalamaShalini V Mohan
Dec 19, 2020·International Journal of Hygiene and Environmental Health·Thomas Theo BrehmAnsgar W Lohse
Feb 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hye SeongJoon Young Song
Feb 14, 2021·Environmental Research·John P A IoannidisDespina G Contopoulos-Ioannidis
Mar 9, 2021·The Lancet. Respiratory Medicine·Christian KaragiannidisReinhard Busse
Mar 13, 2021·Scientific Reports·Thomas Theo BrehmJulian Schulze Zur Wiesch
Jun 19, 2021·Deutsches Ärzteblatt International·Stephan BudweiserAndreas Bauer

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Citations

Aug 28, 2021·Journal of Clinical Medicine·Matteo VassalloChristian Pradier

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