Abstract
Patients with parkinsonism can be classified as clinical definite, probable, possible, or unlikely Parkinson's disease (PD). Possible PD includes patients with PD according to conventional diagnostic criteria and with at least a moderate response to dopamine agonists. However, these patients have clinical features that may reduce the probability for idiopathic PD. The objective of this study was to clinically characterize patients with possible disease in a prevalence study of PD and to indicate the frequency of idiopathic PD in this group of patients. The diagnostic re-evaluation was based on detailed MRI examinations and investigations of dopaminergic drug response after several years of treatment. In a community-based prevalence study in Norway, comprising 245 PD patients, we found 36 patients (15%) with clinical possible PD. The patients with possible disease had significant and clinically important differences in demographic and disease characteristics compared to patients with definite and probable PD. Possible PD patients were older at disease onset, more disabled, and had more neurobehavioral disorders. MRI examinations of 14 of the 36 patients with possible PD in the prevalence study revealed significant group effects ...Continue Reading
References
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
May 1, 1976·Neurology·A Barbeau, M Roy
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jun 1, 1992·Neurology·A J HughesA J Lees
Apr 21, 1990·Lancet·C D Marsden
Jan 1, 1992·Journal of Internal Medicine·H Vestergaard, P Laurberg
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A H RajputA Rajput
Aug 1, 1990·International Journal of Colorectal Disease·M Schweiger, C Rapke
Jan 1, 1989·Neuropathology and Applied Neurobiology·W R Gibb, A J Lees
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·N Quinn
Nov 1, 1989·Neurology·M B SternR I Grossman
Aug 9, 1986·British Medical Journal·N P Quinn, F A Husain
Dec 1, 1986·Annals of Neurology·J R DuguidJ DeGroot
Jun 1, 1985·Neurology·B S SchoenbergA F Haerer
May 1, 1969·European Journal of Pharmacology·J P DaVanzoJ W Ward
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jul 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·N TurjanskiA J Lees
Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·E TandbergJ A Aarli