Patient-derived bladder cancer xenografts: a systematic review

Translational Research : the Journal of Laboratory and Clinical Medicine
Carina BernardoLúcio Santos

Abstract

Patient-derived tumor xenografts (PDTXs) are said to accurately reflect the heterogeneity of human tumors. In the case of human bladder cancer, few studies are available featuring these models. The best methodology to develop and the real value of the model remain unclear. This systematic review aims to elucidate the best methodology to establish and use PDTXs to study the characteristics and behavior of human bladder tumors. The value and potential application of these models are also addressed. A comprehensive literature search was performed to identify published studies using xenograft models directly established from human bladder cancer samples into mice. A total of 12 studies were included in the final analysis. All studies differed in design; the reported take rate varied between 11% and 80%, with the implantation via dorsal incision and with matrigel obtaining the higher take rate. Advanced stage and high-grade tumors were associated with increased take rate. Xenografts preserved the original tumor identity in the establishment phase and after serial passages. Although some studies suggest a correlation between engraftment success and clinical prognosis, evidence about the association between the response of xenografts ...Continue Reading

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Citations

Mar 2, 2017·Nature Reviews. Urology·Takahiro InoueOsamu Ogawa
Feb 20, 2019·Cells·Emi HattoriTadashi Kondo
Jun 23, 2019·Cells·Takahiko Murayama, Noriko Gotoh
Oct 17, 2017·Oncotarget·Andrea PoloSusan Costantini
Jun 9, 2020·Clinical and Translational Medicine·Wei LiuXinghuan Wang
Nov 15, 2018·Frontiers in Oncology·Francesca GiunchiMichelangelo Fiorentino
Dec 7, 2016·Journal of Experimental & Clinical Cancer Research : CR·Luca PompiliCarlo Leonetti
Mar 9, 2018·Frontiers in Oncology·Marissa MattarElisa de Stanchina
Nov 12, 2020·Nature Reviews. Urology·Arjanneke F van de MerbelGabri van der Pluijm

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