Patient-derived cell line, xenograft and organoid models in lung cancer therapy

Translational Lung Cancer Research
Ku-Geng HuoMing-Sound Tsao

Abstract

Lung cancer accounts for most cancer-related deaths worldwide and has an overall 5-year survival rate of ~15%. Cell lines have played important roles in the study of cancer biology and potential therapeutic targets, as well as pre-clinical testing of novel drugs. However, most experimental therapies that have cleared preclinical testing using established cell lines have failed phase III clinical trials. This suggests that such models may not adequately recapitulate patient tumor biology and clinical outcome predictions. Here, we discuss and compare different pre-clinical lung cancer models, including established cell lines, patient-derived cell lines, xenografts and organoids, summarize the methodology for generating these models, and review their relative advantages and limitations in different oncologic research applications. We further discuss additional gaps in patient-derived pre-clinical models to better recapitulate tumor biology and improve their clinical predictive power.

Citations

Jan 14, 2021·Biomaterials Science·Kanishka FernandoEliza Li Shan Fong
Feb 3, 2021·International Journal of Molecular Sciences·Henkie Isahwan Ahmad Mulyadi LaiYi-Ping Yang
Mar 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shimin XieXiao Zhu
Mar 28, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hardyanti Eka PutriPithi Chanvorachote
Aug 6, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Masashi MikuboMing-Sound Tsao
Apr 27, 2021·Cell Regeneration·Tiantian LuYing Xi
Sep 21, 2021·Oncology Letters·Xiulan YangJie Zhang
Nov 12, 2021·Current Protocols·Mohini SinghPriscilla K Brastianos

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