Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix

Cancer Letters
Einar K RofstadJon-Vidar Gaustad

Abstract

Patient-derived xenograft (PDX) models of cancer are considered to reflect the biology and treatment response of human tumors to a larger extent than xenograft models initiated from established cell lines. The characterization of a panel of four novel PDX models of cervical carcinoma of the uterine cervix is described in this communication. The outcome of treatment differed substantially among the donor patients, and the PDX models were found to mirror the histology, aggressiveness, and metastatic propensity of the donor patients' tumors. Two of the models (BK-12 and LA-19) were highly metastatic, one model (ED-15) was poorly metastatic, and one model (HL-16) was non-metastatic. The primary tumors of the two highly metastatic models showed high density of intratumoral lymphatics, whereas the other two models did not develop intratumoral lymphatics. The potential of the models to metastasize to lymph nodes was associated with high expression of both angiogenesis-related genes and cancer stem cell-related genes. The models may be highly valuable for studying mechanisms linking lymph node metastasis to lymphangiogenesis, hemangiogenesis, and the presence of cancer stem cells.

References

Oct 23, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A W FylesR P Hill
Mar 4, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K SundførE K Rofstad
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A FylesR P Hill
Feb 27, 2004·Biochimica Et Biophysica Acta·Yulong HeKari Alitalo
Oct 8, 2005·Angiogenesis·Philippe O Van Trappen, Michael S Pepper
May 10, 2006·Nature Clinical Practice. Oncology·Patricia J Eifel
Aug 8, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marianne NordsmarkJens Overgaard
Aug 22, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anthony FylesRichard P Hill
Mar 16, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Einar K RofstadElse-Beate M Ruud
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J J Waugh, Catherine Wilson
Jan 13, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D HangW-G Xu
Mar 6, 2012·Seminars in Radiation Oncology·Ann H Klopp, Patricia J Eifel
Jul 10, 2012·Seminars in Cancer Biology·Katia Sampieri, Riccardo Fodde
Aug 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Scott KopetzGarth Powis
Oct 12, 2013·Current Oncology Reports·Tara D BarwickAndrea Rockall
Feb 25, 2014·Nature Reviews. Cancer·Steven A StackerMarc G Achen
Sep 4, 2014·Cancer Discovery·Manuel HidalgoAlberto Villanueva
Dec 17, 2014·Cancer Letters·Shuang Li, Qin Li
May 8, 2015·Nature Medicine·Stephen E GouldFrederic J de Sauvage
Jul 17, 2015·Cancer Research·John W CassidyAlejandra Bruna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.