PMID: 11338046May 8, 2001Paper

Patient dosimetry after 131I-MIBG therapy for neuroblastoma and carcinoid tumours

Nuclear Medicine Communications
M A MonsieursR A Dierckx

Abstract

The aim of the study was to determine the equivalent total body dose (ETBD) using the cytokinesis-blocked micronucleus assay in 22 131 I-meta-iodobenzylguanidine (131 I-MIBG) therapies (18 neuroblastoma, mean 5097 MBq, SD 1591; and four carcinoid tumours, mean 7681 MBq, SD 487). The results are correlated with the total body radiation dose according to the Medical Internal Radiation Dosimetry (MIRD) formalism. For each patient, blood samples were taken immediately before and 1 week after 131I-MIBG therapy. The first blood sample was irradiated in vitro with 60Co gamma-rays to determine the dose-response curve. Micronuclei were scored in 1000 binucleated cells. By using the dose-response curve the ETBD was derived from the increase in micronuclei after 131I-MIBG therapy (second blood sample). Based on three consecutive biplanar scans taken at 3, 6 and 9 days post-administration respectively, the total body dose following the MIRD formalism was calculated. The micronucleus assay was evaluable in only 14 out of 22 131I-MIBG therapies due to cell division inhibition caused by previous chemotherapy treatments and lymphocyte dilution due to blood transfusions given shortly after 131I-MIBG therapy. For these 14 therapies, the mean mic...Continue Reading

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Oct 21, 1999·Nuclear Medicine Communications·M A MonsieursR A Dierckx

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Citations

Feb 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Francesco GiammarileUNKNOWN EANM
Feb 25, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ferdinand SudbrockHarald Schicha
Oct 24, 2007·Radiation Protection Dosimetry·Alfredo SernaManuel Canteras
Mar 5, 2016·Radiation Protection Dosimetry·Olivier CougnencHélène Kolesnikov-Gauthier
Jul 2, 2008·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Srinivasan SenthamizhchelvanO Nair
Apr 22, 2017·The Cochrane Database of Systematic Reviews·Kathelijne Cjm KraalBerthe Lf Van Eck-Smit
Jan 11, 2008·Physics in Medicine and Biology·Emma Y SongBarry J Allen
May 21, 2017·Radiation and Environmental Biophysics·Igor K KhvostunovShunichi Yamashita

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