Patient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials

JAMA Network Open
Alyson HaslamVinay Prasad

Abstract

Quality of life (QoL) is an important consideration in cancer medicine, especially because drugs are becoming more costly and may only result in modest gains in overall survival. However, there has been no descriptive analysis for the points at which QoL is measured in cancer trials. To estimate the prevalence of studies that measure QoL at different points and see how many studies measure QoL for the entirety of a patient's life. This cross-sectional analysis includes all articles on oncology clinical trials in the 3 highest-impact oncology journals, published between July 2015 and June 2018, that reported QoL outcomes. Data were abstracted on when QoL was assessed and the characteristics of these studies. For all 149 studies that met inclusion criteria, QoL assessment was high during treatment (104 articles [69.8%]), during follow-up (81 articles [54.4%]), and after the end of the intervention (68 articles [45.6%]). In 5 of the 149 studies (3.4%), QoL was assessed until death, including in only 1 of the 74 studies on metastatic or incurable cancers. Among these 5 studies, only 1 (20%) used a drug intervention, 1 (20%) used a behavioral intervention, and 2 (40%) used a radiation intervention; only 1 of 5 was in the metastatic ...Continue Reading

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Citations

Mar 5, 2020·JAMA Network Open·Hilde M Buiting, Gert Olthuis
May 6, 2021·The Patient·Hannah CollacottSebastian Heidenreich
Jul 17, 2021·Journal of Psychosocial Oncology·Rieneke T LugtenbergMaarten J Fischer
Jul 30, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Shubham SharmaBishal Gyawali

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