Patient Factors Associated With Opioid Consumption in the Month Following Major Surgery.

Annals of Surgery
Daniel B LarachChad M Brummett

Abstract

The aim of this study was to determine preoperative patient characteristics associated with postoperative outpatient opioid use and assess the frequency of postoperative opioid overprescribing. Although characteristics associated with inpatient opioid use have been described, data regarding patient factors associated with opioid use after discharge are lacking. This hampers the development of individualized approaches to postoperative prescribing. We included opioid-naïve patients undergoing hysterectomy, thoracic surgery, and total knee and hip arthroplasty in a single-center prospective observational cohort study. Preoperative phenotyping included self-report measures to assess pain severity, fibromyalgia survey criteria score, pain catastrophizing, depression, anxiety, functional status, fatigue, and sleep disturbance. Our primary outcome measure was self-reported total opioid use in oral morphine equivalents. We constructed multivariable linear-regression models predicting opioids consumed in the first month following surgery. We enrolled 1181 patients; 1001 had complete primary outcome data and 913 had complete phenotype data. Younger age, non-white race, lack of a college degree, higher anxiety, greater sleep disturbance,...Continue Reading

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Citations

Mar 14, 2020·JAMA Network Open·Romesh P NalliahChad M Brummett
Jan 4, 2020·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Afshin A AnoushiravaniRan Schwarzkopf
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Nov 12, 2020·Regional Anesthesia and Pain Medicine·Meredith PaceLori Lyn Price
Nov 6, 2020·Journal of Minimally Invasive Gynecology·Kelli M McEnteeL Elaine Waetjen
Jun 12, 2021·The American Surgeon·Elizabeth M BoudiabSapna Nagar
Jun 22, 2021·Seminars in Arthritis and Rheumatism·Martina D'OnghiaFrancesco Ursini
Jun 30, 2021·The Annals of Thoracic Surgery·Graham Skelhorne-GrossNajib Safieddine
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Dec 1, 2021·Archives of Orthopaedic and Trauma Surgery·Nicholas A GiordanoMichael Kent
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