Patient Factors Associated With Prolonged Postoperative Opioid Use After Total Knee Arthroplasty

The Journal of Arthroplasty
Robert S NambaMaria C S Inacio

Abstract

Pain persists in a moderate proportion of patients after total knee arthroplasty (TKA). Identifying patient factors that are associated with persistent pain may lead to improved care. The purpose of the study was to identify preoperative factors associated with increased opioid prescriptions after TKA. A retrospective cohort study of TKAs in an integrated health-care system (January 2008-December 2011) was conducted. The number of opioid prescriptions per 90-day period after TKA (up to 1 year), was the outcome of interest. Patient risk factors that were evaluated included demographics, pain prescriptions, comorbidities, and chronic pain conditions. Multivariable Poisson regression models were employed. The median age for 23,726 patients was 67 years. Before surgery, 60.0% used opioids. Three months after surgery, 41.2% of patients continued using opioids. Factors associated with greater opioid use included: younger age (odds ratio [OR] = 0.83, 95% confidence interval [CI] 0.82-0.84 per 10-year increase), liver disease (OR = 1.11, 95% CI 1.06-1.16), preoperative nonsteroidal anti-inflammatory drug use (OR = 1.09, 95% CI 1.07-1.10), anxiety (OR = 1.05, 95% CI 1.03-1.08), substance abuse (OR = 1.03, 95% CI 1.00-1.06), diabetes mel...Continue Reading

Citations

May 11, 2019·World Journal of Surgery·Ashley HintherJoseph C Dort
May 17, 2019·The Journal of Bone and Joint Surgery. American Volume·Daniel B C ReidAlan H Daniels
Dec 19, 2019·Pharmacoepidemiology and Drug Safety·Ruchir N KarmaliAndrew W Roberts
Dec 4, 2019·Drugs·Pamela E MacintyreChristine A Huxtable
Jul 16, 2019·The American Journal of Sports Medicine·Anita G RaoGregory B Maletis
Feb 27, 2020·Pharmacoepidemiology and Drug Safety·Xuerong WenKristen A Matteson
Oct 1, 2019·The Journal of Bone and Joint Surgery. American Volume·Heather A PrenticeElizabeth W Paxton
May 28, 2019·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Ronen ShechterMarie N Hanna
Aug 19, 2020·Current Rheumatology Reports·Cade ShadboltMichelle M Dowsey
Jul 14, 2020·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Austin C KaidiThomas R Hickernell
Jan 14, 2021·The Journal of Bone and Joint Surgery. American Volume·Nathan H VaradyAntonia F Chen
Jan 16, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Enrico M ForlenzaBrian Forsythe
Jan 24, 2021·Military Medicine·Muhammad Ali ChaudharyEric Goralnick
May 24, 2020·The Journal of Arthroplasty·Charles A JohnsonChristopher E Gross
Oct 27, 2020·Journal of Orthopaedic Trauma·Carl NunziatoDavid Laverty
Oct 9, 2020·The Journal of Pain : Official Journal of the American Pain Society·Yun ShenAmie J Goodin
Sep 2, 2020·Journal of Shoulder and Elbow Surgery·Anshuman SinghAnita G Rao
May 26, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Kyle N KunzeShane J Nho
Dec 4, 2019·Journal of Voice : Official Journal of the Voice Foundation·Allen L FengPhillip C Song
May 25, 2021·Journal of Clinical Orthopaedics and Trauma·Sravya P VajapeyAndrew I Spitzer
Jun 22, 2021·Seminars in Arthritis and Rheumatism·Martina D'OnghiaFrancesco Ursini
Aug 6, 2021·Anaesthesia and Intensive Care·Pamela E Macintyre
Aug 10, 2021·Foot & Ankle Specialist·Matthew S BroggiJason T Bariteau
Aug 27, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ana JohnsonJoel Parlow
Sep 20, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Hui Ping TayAsad E Patanwala
Dec 1, 2021·Archives of Orthopaedic and Trauma Surgery·Nicholas A GiordanoMichael Kent
Dec 3, 2021·Foot & Ankle International·Wenye SongDaniel C Jupiter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.