Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure

Internal Medicine
Tsuyoshi SuzukiNobuhisa Hagiwara

Abstract

Objective Depression is common in patients with heart failure (HF) and is a possible risk factor for adverse outcomes. The aim of this study was to determine the prevalence of depression assessed by the 2-item Patient Health Questionnaire (PHQ-2) and the effect of depression on outcomes in Japanese outpatients with HF. Methods This sub-analysis of a prospective observational study assessed 976 patients with HF (mean age 66±13 years; 26.7% female; 42.7% with an ischemic etiology). Depression was defined as a PHQ-2 score ≥3. The main composite outcome was death from any cause or hospitalization due to worsening HF. PHQ-2 items were extracted from the PHQ-9 results. To evaluate the association of PHQ-2 scores with outcomes, Cox proportional hazards models were evaluated. Results Fifty-seven (5.8%) patients were diagnosed with depression. During a median follow-up of 21 months, the incidence rates for death from any cause and hospitalization due to worsening HF in patients with and without depression were 2.2 vs. 0.9 per 100 person-years and 6.7 vs. 1.6, p<0.001, respectively. There was a higher incidence of the main outcome in patients with depression than in those without depression (p<0.001). After adjustment for conventional ri...Continue Reading

References

Jul 14, 2001·Journal of the American College of Cardiology·V VaccarinoH M Krumholz
Mar 5, 2002·Archives of Internal Medicine·Kenneth M A MacMahon, Gregory Y H Lip
Oct 30, 2003·Medical Care·Kurt KroenkeJanet B W Williams
Dec 27, 2005·General Hospital Psychiatry·Alexandra MartinElmar Braehler
Oct 19, 2006·Journal of the American College of Cardiology·Thomas RutledgePaul J Mills
Feb 28, 2007·Archives of Internal Medicine·Andrew SherwoodAlan L Hinderliter
Nov 22, 2007·International Journal of Clinical Practice·S A MosovichM E Farkouh
Aug 27, 2009·The Journal of Cardiovascular Nursing·Anne M FinkMariann R Piano
Dec 10, 2009·Psychosomatics·Kurt KroenkeBernd Löwe
Mar 21, 2013·Circulation. Heart Failure·Amanda R MoraskaVéronique L Roger
Nov 28, 2013·European Heart Journal·David L HareTiny Jaarsma
Sep 10, 2014·Journal of Psychosomatic Research·Dionne KessingJohan Denollet
Jul 13, 2016·International Journal of Cardiology·Kunal N BhattVasiliki V Georgiopoulou
Nov 8, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Tsuyoshi SuzukiNobuhisa Hagiwara

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.