Patient-individualized boundary conditions for CFD simulations using time-resolved 3D angiography

International Journal of Computer Assisted Radiology and Surgery
Marco BoegelMarkus Kowarschik

Abstract

Hemodynamic simulations are of increasing interest for the assessment of aneurysmal rupture risk and treatment planning. Achievement of accurate simulation results requires the usage of several patient-individual boundary conditions, such as a geometric model of the vasculature but also individualized inflow conditions. We propose the automatic estimation of various parameters for boundary conditions for computational fluid dynamics (CFD) based on a single 3D rotational angiography scan, also showing contrast agent inflow. First the data are reconstructed, and a patient-specific vessel model can be generated in the usual way. For this work, we optimize the inflow waveform based on two parameters, the mean velocity and pulsatility. We use statistical analysis of the measurable velocity distribution in the vessel segment to estimate the mean velocity. An iterative optimization scheme based on CFD and virtual angiography is utilized to estimate the inflow pulsatility. Furthermore, we present methods to automatically determine the heart rate and synchronize the inflow waveform to the patient's heart beat, based on time-intensity curves extracted from the rotational angiogram. This will result in a patient-individualized inflow velo...Continue Reading

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Citations

Jun 25, 2019·Journal of Biomechanical Engineering·Sergiy ZhukStephen Moore
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Naoki KatoYuichi Murayama

Related Concepts

CT Angiography
Blood Flow Velocity
Mycotic Aneurysm, Intracranial
Cerebral Angiography
In Silico
Radiographic contrast media
Hemodynamics
Imaging, Three-Dimensional, Computer Assisted
Cone-Beam Computed Tomography
Angiogram

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