Patient information leaflets for antidepressants: are patients getting the information they need?

Journal of Affective Disorders
Camilla Haw, Jean Stubbs

Abstract

According to European law a comprehensive patient information leaflet (PIL) has to accompany all medicines. In this study we examined the uniformity, adequacy and balance of information contained in UK antidepressant PILs. We studied antidepressant PILs available in the Electronic Medicines Compendium and subjected each to a content analysis. Words were assessed as being positive, negative or neutral. Forty-two PILs concerning 21 different antidepressants and 23 pharmaceutical companies were studied. PILs presented information about side effects in a strikingly heterogeneous way, making it difficult for patients to find the required information. Half the PILs provided no information about how the antidepressant is thought to work. Over 90% stated the antidepressant would take 2-4 weeks to work, although a few PILs indicated earlier onset of improvement. Not all PILs warned about discontinuation syndrome and advice about alcohol was generally that it was prohibited. Almost half of PILs made no mention of St John's wort and its potential for interaction with the antidepressant. Two-thirds of PILs provided no information about the likely duration of treatment. PILs contained far more words judged to be negative rather than positiv...Continue Reading

Citations

May 10, 2012·Drug, Healthcare and Patient Safety·Sinaa A Al-Aqeel
Dec 8, 2015·Health Information and Libraries Journal·Carla PiresAfonso Cavaco
Aug 15, 2015·Clinical and Experimental Dermatology·W T N Hunt, E J McGrath
Jun 24, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Katherine HarrisPeter Knapp
Dec 10, 2014·Journal of Affective Disorders·Katarzyna MłyniecGabriel Nowak
Oct 23, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·Carla PiresAfonso Cavaco
Feb 3, 2016·Therapeutic Advances in Psychopharmacology·Emma Wilson, Malcolm Lader
Nov 19, 2013·International Journal of Nursing Practice·Nelly D OelkeRebecca Carter

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