Patient-Level and Hospital-Level Risk Factors for In-Hospital Mortality in Patients Ventilated for More Than 24 Hours: Results of a Nationwide Cohort Study.

Journal of Intensive Care Medicine
Olaf SchofferJochen Schmitt

Abstract

Prolonged ventilation is associated with a high risk of death. This study investigated both patient-level and hospital-level risk factors for in-hospital mortality in patients ventilated for more than 24 hours. The analyses were conducted in the framework of a German national multicenter retrospective cohort study. Patient and hospital characteristics were examined using descriptive statistics. Risk factors of in-hospital mortality were analyzed using multilevel robust Poisson regressions for binary outcomes. Potential effect modifications were examined by stratified analyses. The sample includes 95 672 cases of patients ventilated >24 hours in 163 hospitals covering the period 2016 to 2017. According to the results of multilevel Poisson regressions, main patient-level risk factors for in-hospital mortality were age (per year relative risk [RR] = 1.021, 95% CI = 1.020-1.023), stroke (RR = 1.459; 95% CI = 1.361-1.563), emergency case admission (RR = 1.273, 95% CI = 1.156-1.403), and transfer from another hospital (RR = 1.169, 95% CI = 1.084-1.261). The individual risk of in-hospital death was positively associated with hospital size (RR of hospitals with 600-799 beds vs <100 beds = 1.412, 95% CI = 1.095-1.820) and negatively rel...Continue Reading

References

Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Dec 26, 2002·Journal of Critical Care·Ron Ben-AbrahamGideon Paret
Jan 17, 2004·American Journal of Respiratory and Critical Care Medicine·Jerry A KrishnanHenry E Fessler
Jul 11, 2006·The New England Journal of Medicine·Jeremy M KahnGordon D Rubenfeld
Jul 20, 2010·Critical Care Medicine·Hannah WunschJeremy M Kahn
May 17, 2011·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·A James MamaryGerard J Criner
Nov 11, 2011·Statistical Methods in Medical Research·G Y Zou, Allan Donner
Nov 15, 2011·Critical Care Medicine·Shannon S CarsonUNKNOWN ProVent Investigators
Oct 23, 2012·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Ines Chop, Maria Eberlein-Gonska
Dec 25, 2015·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Thomas ManskyUlrike Nimptsch
Jul 18, 2016·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·W KrahwinkelUNKNOWN For the HELIOS Medical Board and HELIOS Working Group on Peer Reviewing
Feb 1, 2018·Respiratory Care·Maria Dolores Fernandez-ZamoraUNKNOWN ARIAM Andalucía Group
Dec 27, 2018·Critical Care Medicine·Anuj B MehtaIvor S Douglas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved