Patient perspectives on molecular tumor profiling: "Why wouldn't you?"

BMC Cancer
Megan BestMembers of the PiGeOn Project

Abstract

This study explored the attitudes of patients with advanced cancer towards MTP and return of results, prior to undergoing genomic testing within a research program. Participants were recruited as part of the longitudinal PiGeOn (Psychosocial Issues in Genomics in Oncology) study involving patients with advanced/metastatic solid cancer who had exhausted therapeutic options and who were offered MTP in order to identify cognate therapies. Twenty patients, selected by purposive sampling, were interviewed around the time they gave consent to MTP. Interviews were audio recorded, transcribed and analysed using thematic analysis. Themes identified in the transcripts were cross-validated via qualitative responses to the PiGeOn study survey (n = 569; 63%). All interviewed participants gave consent to MTP without reservation. Three themes were identified and further supported via the survey responses: (1) Obvious agreement to participate, primarily because of desire for new treatments and altruism. (2) The black box - while participant knowledge of genomics was generally poor, faith in their oncologists and the scientific process encouraged them to proceed with testing; and (3) Survival is the priority - receiving treatment to prolong lif...Continue Reading

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Citations

May 15, 2020·JAMA Network Open·Phyllis ButowUNKNOWN PiGeOn Project
Jun 17, 2020·Psycho-oncology·Megan BestUNKNOWN And members of the PiGeOn Project
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Erica Ramos
Sep 5, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Theresia PichlerUte Goerling
Jul 10, 2021·Journal of the National Cancer Institute·William M P KleinRobin C Vanderpool
Nov 11, 2021·American Journal of Medical Genetics. Part a·Bettina MeiserUNKNOWN Members of the Psychosocial Issues in Genomics in Oncology (PiGeOn) Project

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Software Mentioned

PiGeOn
MoST

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