Patient pools and the use of "patient means" are valuable tools in quality control illustrated by a bone-specific alkaline phosphatase assay

Clinical Chemistry and Laboratory Medicine : CCLM
Maja HingeJonna S Madsen

Abstract

Quality control (QC) is an essential part of clinical biochemistry to ensure that laboratory test results are reliable and correct. Those tests without a defined reference method constitute a special challenge, as is the case with bone-specific alkaline phosphatase (BAP). The present study reports an example where a shift in a BAP assay was detected by use of a patient pool and supported by a retrospective calculation of "patient mean", while the external QC and specific assay control material were unaffected by the shift. Patient pools and the use of patient means remain a useful and inexpensive procedure for internal QC.

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Citations

Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Huub H van Rossum, Hans Kemperman
Oct 12, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Huub H van Rossum
Jul 9, 2020·Clinical Chemistry·Andreas BietenbeckTony Badrick
Aug 16, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Huub H van Rossum, Hans Kemperman
Jun 14, 2020·The Journal of Applied Laboratory Medicine·Huub H van Rossum, Daan van den Broek
Mar 11, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Huub H van RossumTony C Badrick
Sep 15, 2021·Journal of Clinical Laboratory Analysis·Yuanyuan LiXiaoling Chen

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