Patient preferences for interferon alfa in multiple myeloma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
H LudwigB G Durie

Abstract

Interferon alfa treatment in multiple myeloma marginally improves relapse-free and overall survival. Often it does so at the expense of toxicity and financial cost. If patients are unwilling or unable to participate in the decision of whether to initiate such treatment, known patient preferences can serve as guidelines for the physician. We interviewed myeloma patients in the United States to obtain information that might facilitate medical decision-making. Three hundred fifty-five myeloma patients throughout the United States were interviewed by telephone. Without identifying interferon alfa as the treatment agent, interviewers described potential adverse effects, financial cost, and self-injection procedures. The potential benefits of four treatment choices, derived from a meta-analysis of published data, were presented as gains in remission rate (+10%), remission duration (an additional 4 and 7 months, respectively, for induction and maintenance treatment), and overall survival (an additional 3 and 6 months, respectively, for induction and maintenance treatment). Patients' choices for or against use of the unidentified substance were recorded, and interferon was subsequently disclosed as the treatment. The profiles of patien...Continue Reading

Citations

Sep 6, 2000·Journal of Internal Medicine·G Gahrton, B Björkstrand
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·C Shustik
Sep 5, 2002·Arthritis and Rheumatism·Liana FraenkelJohn Concato
Dec 10, 2017·Hematology·Heinz Ludwig, Niklas Zojer
Mar 20, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bruce R SchackmanIra M Jacobson
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M Stiggelbout, J C de Haes
Jul 10, 2001·British Journal of Haematology·UNKNOWN Myeloma Trialists' Collaborative Group
Aug 12, 1999·British Journal of Haematology·H M LokhorstL F Verdonck

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