Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment

The British Journal of Dermatology
D KopaskerP F Allanson

Abstract

The treatment of actinic keratosis (AK) is a potentially effective strategy for the prevention of cutaneous squamous cell carcinoma (cSCC). However, the patient perspective on potential benefits of AK treatment in terms of skin cancer reduction has received little attention to date. (i) To investigate patient preferences for topical treatments for AK using a discrete-choice experiment (DCE); (ii) to evaluate patient willingness to trade between clinical benefit and medical burden. The DCE was conducted as part of a study to establish the feasibility of a phase III randomized controlled trial evaluating the prevention of cSCC using currently available topical interventions. Preferences were elicited by asking patients to make a series of choices between treatment alternatives with different hypothetical combinations of attribute levels. Willingness to trade between treatment attributes was estimated using a flexible-choice model that allows for the heterogeneity of patient preferences. A total of 109 patients with AK completed the DCE. The majority of patients who expressed valid preferences were willing to accept some reduction in both prophylactic and cosmetic efficacy to reduce the burden of the treatment regimen, the severit...Continue Reading

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Citations

Apr 2, 2019·The British Journal of Dermatology·D de Berker
Jun 23, 2020·The British Journal of Dermatology·M Samimi, N Kelleners-Smeets
Feb 3, 2021·Dermatologic Therapy·Ayman GradaGiovanni Damiani
Jun 17, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Paul F AllansonAndrzej Kwiatkowski

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