Patient profiling for success after weight loss surgery (GO Bypass study): An interdisciplinary study protocol

Contemporary Clinical Trials Communications
Bodil Just ChristensenAnders Sjödin

Abstract

Despite substantial research efforts, the mechanisms proposed to explain weight loss after gastric bypass (RYGB) and sleeve gastrectomy (SL) do not explain the large individual variation seen after these treatments. A complex set of factors are involved in the onset and development of obesity and these may also be relevant for the understanding of why success with treatments vary considerably between individuals. This calls for explanatory models that take into account not only biological determinants but also behavioral, affective and contextual factors. In this prospective study, we recruited 47 women and 8 men, aged 25-56 years old, with a BMI of 45.8 ± 7.1 kg/m2 from the waiting list for RYGB and SL at Køge hospital, Denmark. Pre-surgery and 1.5, 6 and 18 months after surgery we assessed various endpoints spanning multiple domains. Endpoints were selected on basis of previous studies and include: physiological measures: anthropometrics, vital signs, biochemical measures and appetite hormones, genetics, gut microbiota, appetite sensation, food and taste preferences, neural sensitivity, sensory perception and movement behaviors; psychological measures: general psychiatric symptom-load, depression, eating disorders, ADHD, pers...Continue Reading

Associated Clinical Trials

Citations

Feb 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Mette S NielsenAnders Sjödin
Apr 7, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Elisa Morales-MarroquinSarah E Messiah
Oct 12, 2018·Journal of Eating Disorders·Louise TækkerSusanne Lunn
Apr 25, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mette S NielsenAnders Sjödin
Apr 1, 2021·Obesity Surgery·Mette S NielsenAnders Sjödin
Jul 8, 2019·Neuroendocrinology·José Ramón Muñoz-RodríguezLuis F Alguacil

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Methods Mentioned

BETA
gastric bypass

Clinical Trials Mentioned

NCT02070081
NCT00939679

Software Mentioned

Illumina Genome Studio
Full4Healt

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