Patient-prosthesis mismatch after transapical aortic valve implantation: incidence and impact on survival

The Journal of Thoracic and Cardiovascular Surgery
Marian KukuckaAxel Unbehaun

Abstract

Transcatheter aortic valve implantation (TAVI) has become an important therapeutic option for high-risk patients with severe aortic valve stenosis. Patient-prosthesis mismatch (P-PM) is an important determinant of morbidity and mortality after open aortic valve replacement. The objective of our study was to evaluate P-PM incidence and its impact on survival in a large cohort of patients treated with TAVI. We retrospectively analyzed transesophageal echocardiographic data of 278 consecutive patients (Society of Thoracic Surgeons score 18.5 ± 15.3, age 80 ± 8 years) who underwent transapical TAVI with Edwards Sapien valves between April 2008 and March 2011. Effective orifice area was calculated using the continuity equation and indexed with body surface area (iEOA). P-PM was stratified as severe (iEOA < 0.65 cm(2)/cm(2)) and moderate (iEOA, 0.65-0.85 cm(2)/m(2)). Midterm survival (up to 30 months) was analyzed by Kaplan-Meier curves and log-rank tests. There was no P-PM in 181 (65.1%) patients; moderate P-PM was found in 76 (27.3%) patients and severe P-PM in 21 (7.6%). Thirty-day survival was 96.0%, 97.3%, and 90.5%. The 3-month survival was 91%, 90%, and 66%, respectively (P = .0013). Combination of severe P-PM with peak pressu...Continue Reading

References

Jul 1, 1978·Circulation·S H Rahimtoola
Oct 12, 2000·Journal of the American College of Cardiology·P Pibarot, J G Dumesnil
May 26, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Neil J HowellDomenico Pagano
May 30, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Thomas WaltherJan F Gummert
Dec 23, 2008·The Annals of Thoracic Surgery·Thomas WaltherMichael Mack
Jan 1, 2008·JACC. Cardiovascular Imaging·Robert R MossJohn G Webb
May 16, 2009·Journal of the American College of Cardiology·Marie-Annick ClavelJosep Rodés-Cabau
Aug 5, 2009·Circulation·Frank WeidemannJörg M Strotmann
May 25, 2010·The Annals of Thoracic Surgery·Miralem PasicRoland Hetzer
Oct 26, 2010·The Annals of Thoracic Surgery·Miralem PasicRoland Hetzer
Nov 26, 2010·The Journal of Thoracic and Cardiovascular Surgery·Miralem PasicRoland Hetzer
Aug 27, 2011·Journal of the American College of Cardiology·Dimitri KalavrouziotisEric Dumont

❮ Previous
Next ❯

Citations

Oct 18, 2013·General Thoracic and Cardiovascular Surgery·Kentaro Honda, Yoshitaka Okamura
Sep 24, 2014·AJR. American Journal of Roentgenology·Ajit H GoenkaMilind Y Desai
Feb 3, 2016·The Annals of Thoracic Surgery·Hisato TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Oct 24, 2013·Journal of Cardiovascular Computed Tomography·Melanie FreemanJonathon Leipsic
Apr 9, 2016·JACC. Cardiovascular Imaging·Christopher NaoumJonathon Leipsic
Mar 7, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Frederick C CobeyJohn G Augoustides
May 30, 2016·JACC. Cardiovascular Imaging·Victor DayanPhilippe Pibarot
Oct 1, 2016·Current Treatment Options in Cardiovascular Medicine·Abdellaziz DahouPhilippe Pibarot
Jul 20, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Derrick Y TamStephen E Fremes
Aug 25, 2018·Future Cardiology·Colin M Barker, Michael J Reardon
Jun 22, 2018·Interventional Cardiology·Makoto Nakashima, Yusuke Watanabe
Sep 1, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Vasileios F PanoulasUNKNOWN WIN-TAVI Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.