PMID: 20650026Jul 24, 2010Paper

Patient-reported adverse drug-related events from emergency department discharge prescriptions

CJEM
C M HohlRoy A Purssell

Abstract

The tolerability of drugs prescribed on emergency department (ED) discharge is unknown. Our objectives were to quantify and describe adverse drug-related events (ADREs) as reported by patients triaged as Canadian Emergency Department Triage and Acuity Scale scores 3, 4 or 5, discharged from the ED with prescriptions. This prospective observational study was a planned substudy of a larger study on adherence to discharge prescriptions. This study was conducted in a tertiary care centre with an annual ED census of 69 000 visits. The primary outcome was the frequency of ADREs reported during a structured telephone questionnaire 2 weeks after ED discharge. An ADRE was deemed to have occurred if the patient reported a symptom consistent with a known ADRE that began and resolved within a plausible time frame after starting and stopping the drug, and if no alternative diagnosis was probable. Research assistants contacted 258/301 (85.7%) patients discharged from the ED with a prescription. An ADRE was reported by 54/258 patients (20.9%, 95% confidence interval [CI] 16.4%-26.3%). The most commonly reported ADREs were nausea, constipation and drowsiness. None required hospital admission or caused death. Participants reporting ADREs were n...Continue Reading

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Jun 4, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Peter J ZedRoy A Purssell
Mar 11, 2009·CJEM·Corinne M HohlRoy A Purssell

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Citations

May 4, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anjan K Banerjee, Simon Ingate
Sep 20, 2011·Pain Practice : the Official Journal of World Institute of Pain·Joseph V PergolizziKent H Summers

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