Patient-reported flare frequency is associated with diminished quality of life and family role functioning in systemic lupus erythematosus

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Patricia KatzMichael L Reed

Abstract

To understand the influence of the systemic lupus erythematosus (SLE)-related flares on patient's health-related quality of life (HRQoL). An online survey included individuals with self-reported physician's diagnosis of SLE or lupus nephritis (LN). Lupus impact tracker (LIT) assessed lupus symptoms and HRQoL, SLE-Family questionnaire measured family role functioning, and Healthy Days Core Module (HDCM) measured overall mental and physical health. Chi-square and analysis of variance evaluated differences by flare frequency. Multivariable linear regression and generalized linear models evaluated the independent relationships of flare frequency to HRQoL. 1066 respondents with SLE or LN completed the survey. Mean (SD) duration of illness was 12.4 (10.1) years. 93.4% (n = 996) were women, 82.3% (n = 830) were White, and 49.7% (n = 530) were employed or students. More frequent flares were associated with significantly worse scores on all HRQoL measures: LIT (adjusted means: 0 flares, 31.8; 1-3 flares, 47.0; 4-6 flares, 56.1; ≥ 7 flares, 63.6; P < 0.001); SLE-Family (adjusted means: 0 flares, 3.1; 1-3 flares 3.8; 4-6 flares, 4.3; ≥ 7 flares, 4.6, P < 0.001); HDCM unhealthy days (0 flares, 8.7; 1-3 flares, 17.4; 4-6 flares, 21.5; ≥ 7 f...Continue Reading

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Feb 28, 2020·Journal of Managed Care & Specialty Pharmacy·Patricia KatzMichael L Reed

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Citations

Nov 26, 2020·International Journal of Environmental Research and Public Health·Elena Castellano-RiojaAna Soto-Rubio
Jan 5, 2021·Expert Review of Clinical Immunology·Samuel de Oliveira AndradeSimone Appenzeller
Aug 14, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N BoykoM E Guseva

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