Patient-Reported Functional Status in Outpatients With Advanced Cancer: Correlation With Physician-Reported Scores and Survival

Journal of Pain and Symptom Management
Gordana PopovicCamilla Zimmermann

Abstract

Performance status measures are increasingly completed by patients in outpatient cancer settings, but are not well validated for this use. We assessed performance of a patient-reported functional status measure (PRFS, based on the Eastern Cooperative Oncology Group [ECOG]), compared with the physician-completed ECOG, in terms of agreement in ratings and prediction of survival. Patients and physicians independently completed five-point PRFS (lay version of ECOG) and ECOG measures on first consultation at an oncology palliative care clinic. We assessed agreement between PRFS and ECOG using weighted Kappa statistics, and used linear regression to determine factors associated with the difference between PRFS and ECOG ratings. We used the Kaplan-Meier method to estimate the patients' median survival, categorized by PRFS and ECOG, and assessed predictive accuracy of these measures using the C-statistic. For the 949 patients, there was moderate agreement between PRFS and ECOG (weighted Kappa 0.32; 95% CI: 0.28-0.36). On average, patients' ratings of performance status were worse by 0.31 points (95% CI: 0.25-0.37, P < 0.0001); this tendency was greater for younger patients (P = 0.002) and those with worse symptoms (P < 0.0001). Both PR...Continue Reading

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Citations

Oct 3, 2020·Cancer·Michelle I Higgins, Viraj A Master
Oct 3, 2018·CA: a Cancer Journal for Clinicians·David HuiEduardo Bruera
Jun 13, 2020·BMJ Supportive & Palliative Care·Sorayya AlamBreffni Hannon
Jun 25, 2020·International Journal of Molecular Sciences·Gaia GiannoneGiorgio Valabrega
Jul 1, 2020·JCO Clinical Cancer Informatics·Zaki HasnainJorge Nieva
Apr 21, 2020·CA: a Cancer Journal for Clinicians·Heather S L JimPeter A S Johnstone
Dec 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Emily C HarroldSinead Cuffe
Apr 9, 2021·Current Treatment Options in Oncology·Jean MathewsCamilla Zimmermann

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