Patient-reported long-term rectal function after permanent interstitial brachytherapy for clinically localized prostate cancer

Brachytherapy
Peter F OrioKent Wallner

Abstract

To evaluate the effect of permanent interstitial brachytherapy with or without supplemental therapies on long-term rectal function using a patient-administered quality-of-life instrument. One hundred thirty four of the initial 219 prostate brachytherapy patients who remain alive and have participated in a prospective evaluation of rectal function were mailed the rectal function assessment score (R-FAS). Of the 134 patients, 3 have a colostomy because of colorectal cancer, 2 failed to respond, and 129 (99.2% of eligible patients) returned a completed R-FAS. R-FAS ranges from 0 to 27 with lower scores indicative of better bowel function. Median followup was 14 years. Multiple clinical, treatment, and dosimetric parameters were evaluated for impact on bowel function. For the current cohort, R-FAS was 3.35, which was comparable to the 1999 (4.29), 2002 (3.92), and 2006 (4.00) surveys. In the 2011 survey, 10 (7.8%), 17 (13.1%), and 102 (78.3%) patients reported bowel function to be worse, improved, or unchanged after brachytherapy. No patient has developed a rectal ulcer or fistula. The number of preimplant bowel movements, tobacco, and diabetes mellitus correlated with R-FAS. Consistent with the previous thee surveys, patient's per...Continue Reading

References

Nov 7, 2000·Cancer·D TheodorescuP G Koutrouvelis
Nov 20, 2003·Urology·Gregory S MerrickWayne M Butler
Aug 23, 2005·International Journal of Radiation Oncology, Biology, Physics·Audrey TranWayne Butler
May 4, 2007·The Cancer Journal·Gregory S MerrickJonathan Lief
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Al V TairaKent E Wallner

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Citations

Apr 8, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Wayne M Butler, Gregory S Merrick
Jun 20, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-M CossetL Chauveinc

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