Patient-reported multiple drug reactions: clinical profile and results of challenge testing

Indian Journal of Dermatology, Venereology and Leprology
M RamamRakesh K Chadda

Abstract

Some patients report hypersensitivity reactions to many drugs making it difficult to prescribe medications when they fall ill. To describe the clinical profile of multiple drug hypersensitivity and the results of challenge testing in a large teaching hospital. We performed a five-year retrospective review of the records of patients who complained of reactions to two or more unrelated drugs and avoided medication because of a fear of developing reactions. Oral challenge testing was carried out in hospital with drugs suspected by the patient to cause reactions and/or commonly prescribed medications. A positive reaction was diagnosed when symptoms and signs resembled previously experienced episodes and there was no such reaction with placebo. Twenty three patients (aged 14-65 years; 19 females) underwent challenge testing. Their complaints had been present for 1-30 years, with 2-40 drug reaction episodes reported. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) were most commonly implicated, and urticaria/angioedema were the most often reported manifestations. The patients underwent 3-27 challenges with 1-24 drugs. Three had positive challenge reactions with various NSAIDs, 13 developed symptoms and signs that were ...Continue Reading

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Citations

Aug 22, 2014·Current Allergy and Asthma Reports·Roland Solensky, David A Khan
Jan 17, 2015·Indian Dermatology Online Journal·Tejas K PatelDc Sharma
Dec 19, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David A Khan
Jan 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leon KaoDavid A Khan
Feb 1, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eric Macy, Ngoc J Ho
Aug 12, 2015·Indian Journal of Dermatology, Venereology and Leprology·Saurabh SinghVinod K Sharma
Nov 13, 2018·Current Clinical Pharmacology·Sapan K BeheraSandhiya Selvarajan

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