Patient reported outcome in posttraumatic pituitary deficiency: results from The Danish National Study on posttraumatic hypopituitarism

European Journal of Endocrinology
M KloseU Feldt-Rasmussen

Abstract

Posttraumatic pituitary hormone deficiency is often suggested. The impact of these predominantly mild and often irreproducible deficiencies on outcome is less clear. The aim of the present study was to describe patient reported outcome in a national a priori unselected cohort of patients with traumatic brain injury (TBI) in relation to deficiencies identified upon pituitary assessment. We conducted a nationwide population-based cohort study. Participants were Danish patients with a head trauma diagnosis recorded in the Danish Board of Health diagnostic code registry; 439 patients (and 124 healthy controls) underwent assessment of anterior pituitary function 2.5 years (median) after TBI. Questionnaires on health-related quality of life (QoL) (SF36, EuroQoL-5D, QoL assessment of GH deficiency in adults) and fatigue (MFI-20) were completed in parallel to pituitary assessment. Patients with TBI had significant detriments in QoL. Impairment (mainly physical scales) related to pituitary deficiency, although only partially confirmed after adjustment for demographic differences. Hypogonadotropic hypogonadism related to several QoL scores. Increasing impairments were observed with declining total testosterone concentrations (men), but n...Continue Reading

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Citations

Aug 5, 2015·Journal of Clinical Medicine·Christine Streetz-van der WerfIlonka Kreitschmann-Andermahr
Aug 5, 2015·Journal of Clinical Medicine·Marianne Klose, Ulla Feldt-Rasmussen
Jan 19, 2016·Annales d'endocrinologie·A-L Lecoq, P Chanson
Sep 9, 2017·Nature Reviews. Endocrinology·Marianne Klose, Ulla Feldt-Rasmussen
May 12, 2018·Endocrine Connections·H A BooijH M den Hertog
Jul 27, 2020·Endocrinology, Diabetes & Metabolism·Meriem BensalahSamia Ould Kablia

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.