Patient-reported outcomes in meta-analyses-part 2: methods for improving interpretability for decision-makers

Health and Quality of Life Outcomes
Bradley C JohnstonG Guyatt

Abstract

Systematic reviews and meta-analyses of randomized trials that include patient-reported outcomes (PROs) often provide crucial information for patients, clinicians and policy-makers facing challenging health care decisions. Based on emerging methods, guidance on improving the interpretability of meta-analysis of patient-reported outcomes, typically continuous in nature, is likely to enhance decision-making. The objective of this paper is to summarize approaches to enhancing the interpretability of pooled estimates of PROs in meta-analyses. When differences in PROs between groups are statistically significant, decision-makers must be able to interpret the magnitude of effect. This is challenging when, as is often the case, clinical trial investigators use different measurement instruments for the same construct within and between individual randomized trials. For such cases, in addition to pooling results as a standardized mean difference, we recommend that systematic review authors use other methods to present results such as relative (relative risk, odds ratio) or absolute (risk difference) dichotomized treatment effects, complimented by presentation in either: natural units (e.g. overall depression reduced by 2.4 points when m...Continue Reading

References

Jan 1, 1991·Journal of Clinical Epidemiology·S Suissa
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Apr 2, 1998·BMJ : British Medical Journal·G H GuyattR S Goldstein
May 21, 1999·Lancet·T A Furukawa
Apr 9, 2002·Mayo Clinic Proceedings·Gordon H GuyattUNKNOWN Clinical Significance Consensus Meeting Group
Jan 11, 2005·The European Respiratory Journal·H J SchünemannG H Guyatt
May 9, 2006·Home Healthcare Nurse·Doris J Mosocco
Sep 16, 2006·Health and Quality of Life Outcomes·Holger J SchünemannGordon H Guyatt
Sep 18, 2007·Journal of Clinical Psychopharmacology·Toshi A FurukawaTeruhiko Higuchi
Jan 30, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Corrado BarbuiAndrea Cipriani
Feb 24, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M A BartoliA Branchereau
Oct 1, 2004·Expert Review of Pharmacoeconomics & Outcomes Research·Sepideh S FarivarRon D Hays
May 22, 2010·Journal of Psychosomatic Research·Toshi A Furukawa
Mar 31, 2011·Journal of Clinical Epidemiology·Jan O FriedrichJoseph Beyene
May 11, 2011·PloS One·Toshi A Furukawa, Stefan Leucht
Aug 10, 2011·Statistics in Medicine·Judith Anzures-CabreraJulian Pt Higgins
May 23, 2012·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Jun 2, 2012·Journal of Clinical Epidemiology·Bradley C JohnstonGordon H Guyatt
Nov 3, 2012·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schunemann
Jul 3, 2013·Health and Quality of Life Outcomes·Bradley C JohnstonGordon H Guyatt

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Citations

Mar 8, 2014·Systematic Reviews·Aaron L LeppinJon C Tilburt
May 2, 2014·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Monika Bullinger
Oct 3, 2015·BMJ Open·Bradley C JohnstonGihad Nesrallah
Aug 30, 2014·Health and Quality of Life Outcomes·Kristofer Bandayrel, Bradley C Johnston
Jun 28, 2015·Clinical Orthopaedics and Related Research·Ydo Vincent Kleinlugtenbelt, Mohit Bhandari
Dec 31, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mirjam A G Sprangers
Oct 12, 2018·The Cochrane Database of Systematic Reviews·Eu Chang HwangPhilipp Dahm
Nov 10, 2017·The Cochrane Database of Systematic Reviews·Carolyne PehoraBradley Johnston
Apr 24, 2019·Research and Practice in Thrombosis and Haemostasis·Barbara A KonkleAlfonso Iorio
Dec 3, 2016·Physiotherapy Canada. Physiothérapie Canada·Silvia GianolaLorenzo Moja

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