Patient-reported side effects of intradetrusor botulinum toxin type a for idiopathic overactive bladder syndrome

Urologia Internationalis
Ricarda M BauerFlorian May

Abstract

The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Botulinum toxin A injection was performed in 56 patients with idiopathic OAB. Patients were followed up for 6 months concerning side effects and patients' satisfaction. Different types of side effects were assessed such as dry mouth (19.6%), arm weakness (8.9%), eyelid weakness (8.9%), leg weakness (7.1%), torso weakness (5.4%), impaired vision (5.4%) and dysphagia (5.4%). In all cases, symptoms were mild and transient. Urological complications such as gross hematuria (17.9%), acute urinary retention (8.9%) and acute urinary tract infection (7.1%) were noticed. In all cases, acute urinary retention was transient and treated with temporary intermittent self-catheterization. There was no statistically significant correlation between dosage and observed side effects. Patients' satisfaction rate was high (71.4%). Intradetrusor injection of botulinum toxin was associated with a high rate of neurourological side effects. In general, side effects were transient, mild and did not require special treatment.

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Citations

Oct 18, 2011·World Journal of Urology·Douglas G Tincello
Sep 15, 2012·Biologics : Targets & Therapy·Aziz Gulamhusein, Altaf Mangera
Apr 28, 2012·European Urology·Ricarda M Bauer, Christian Gratzke
Sep 16, 2015·Neurourology and Urodynamics·Kathleen BeusterienSandip Vasavada
Sep 9, 2015·International Urology and Nephrology·Hashim HashimLinda Cardozo
Jun 5, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jie ZhangMingming Cai
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Jan 9, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Osama AbdelwahabAly Eshazly
Jul 13, 2017·Scandinavian Journal of Urology·Frederikke Eichner ChristiansenHans Jørgen Kirkeby
Feb 13, 2013·Pharmacotherapy·Jack J Chen, Khashayar Dashtipour
Jan 26, 2012·International Urogynecology Journal·Linda BrubakerKarl-Dietrich Sievert
Jan 5, 2021·Current Opinion in Urology·Hatim ThakerMin Dong

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