Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study.

Head & Neck
Rebecca T KarstenAndy R Ness

Abstract

Single-modality treatment (surgery or radiotherapy [RT]) is a curative treatment option for early-stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self-reported swallowing function. Participants with a T1-2N0-2bM0 OPC who were offered single-modality treatment and were recruited to the Head and Neck 5000 study were included. Prospectively collected self-reported swallowing function was compared between surgery and RT. Those offered RT (n = 150) had less favorable baseline characteristics than those offered surgery (n = 150). At 12-month follow up, RT participants reported more swallowing problems (35% vs 23%, RR 1.3; 95% CI 0.8-2.3, P = .277) in models adjusted for baseline characteristics. In those allocated to surgery who received adjuvant therapy (n = 78, 52%), the proportion with swallowing problems was similar to those allocated to RT alone. Participants offered surgery alone had similar mortality but improved swallowing, although this was not statistically significant. However, over half of participants offered surgery alone received surgery and adjuvant therapy.

References

Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·K K AngL J Peters
Jul 13, 2002·Cancer·James T ParsonsRodney R Million
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Jul 13, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Janet A WilsonJoanne M Patterson
Nov 23, 2011·Archives of Otolaryngology--head & Neck Surgery·Catherine F SinclairJ Scott Magnuson
Apr 12, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Peter T DziegielewskiEnver Ozer
May 4, 2013·Cancer·Katherine A HutchesonF Christopher Holsinger
Nov 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Mar 20, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Katherine A HutchesonJan S Lewin
Jul 3, 2015·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·J O'HaraJ Patterson
Oct 6, 2015·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·A R NessUNKNOWN Head and Neck 5000 Study Team
Mar 19, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·M Evans, T M Jones
Nov 20, 2016·Journal of Oncology Practice·Meghan T TurnerRobert L Ferris
Dec 13, 2016·The Cochrane Database of Systematic Reviews·James HowardChris Nutting
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Danielle RodinBrian O'Sullivan
Mar 30, 2018·Clinical and Translational Radiation Oncology·Catia PedroFilomena Santos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zeitschrift für Tropenmedizin und Parasitologie
F KOBERLE, E NADOR
Hellenika stomatologika chronika. Hellenic stomatological annals
G Adamide
Acta Oto-laryngologica
S PODVINEC
Proceedings of the Royal Society of Medicine
G M ARDRAN, F H KEMP
© 2021 Meta ULC. All rights reserved