Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer.

Cancer
Kirsten A NyropHyman B Muss

Abstract

To the authors' knowledge, it is unknown whether patient-reported symptom severity and symptom interference with daily activities differ between younger (aged <65 years) and older (aged ≥65 years) women receiving similar chemotherapy regimens for early breast cancer (EBC). Study participants rated 17 side effects of chemotherapy regimens currently in use in clinical practice (2014-2019). Of 284 women with EBC (stage I-III), approximately 57% were aged <65 years and 43% were aged ≥65 years. For anthracycline-based regimens, a higher percentage of younger women reported moderate, severe, or very severe (MSVS) hot flashes (49% vs 18%) (P < .001). For nonanthracycline regimens, a higher percentage of younger women reported MSVS hot flashes (38% vs 19%) (P = .009) and a lower percentage reported MSVS arthralgia (28% vs 49%) (P = .005). With regard to symptom interference with daily activities, a higher percentage of younger women being treated with anthracycline-based regimens reported MSVS hot flashes (32% vs 7%) (P = .001) and myalgia (38% vs 18%) (P = .02). For nonanthracycline chemotherapy, a higher percentage of younger women reported MSVS interference for hot flashes (26% vs 9%) (P = .006) and lower percentages reported abdomi...Continue Reading

References

Jul 2, 2010·Oncology Nursing Forum·Carol A EnderlinAllen C Sherman
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin D SmithThomas A Buchholz
May 18, 2013·Breast Cancer Research and Treatment·Rachel A FreedmanUNKNOWN Alliance for Clinical Trials in Oncology
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy J JudsonEthan Basch
May 23, 2014·Breast Cancer Research and Treatment·M F BarginearA Hurria
Jul 10, 2014·Journal of the National Cancer Institute·Bryce B ReeveDeborah Watkins Bruner
Nov 29, 2015·Clinics in Geriatric Medicine·Meghan KaruturiHyman Muss
Jan 16, 2016·Women's Health·Trevor A JollyHyman B Muss
Sep 8, 2016·Journal of Oncology Practice·Angela M Stover, Ethan M Basch
Dec 20, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachel A FreedmanArti Hurria
Apr 2, 2017·Breast Cancer Research and Treatment·Jeanne S MandelblattArti Hurria
Mar 11, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·William J GradisharDorothy A Shead

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