Patient-selected goals in overactive bladder: a placebo controlled randomized double-blind trial of transdermal oxybutynin for the treatment of urgency and urge incontinence

BJU International
Rufus CartwrightDudley Robinson

Abstract

To assess patient selected goal improvement with transdermal oxybutynin, in a representative population of adult women with overactive bladder (OAB). Adult women with ≥ 3 month history of OAB symptoms, with or without urgency urinary incontinence, were recruited from a tertiary referral urogynaecology unit. Participants were allocated to either transdermal oxybutynin 3.9 mg/day or matching placebo patches in a double-blind, randomized parallel group design, over 4 weeks. Patient-selected goal achievement was defined as the primary outcome measure. Participants selected their own goals for treatment at baseline, and subsequently scored achievement of these goals on a visual analogue scale. They completed 3-day bladder diaries incorporating the Patients Perception of Intensity of Urgency Scale (PPIUS) to assess urgency and urgency incontinence episodes. Quality of life was assessed using the King's Health Questionnaire (KHQ). A total of 96 women were randomized; 78 (81.3%) participants completed 4 weeks double-blind treatment. There was no significant difference between mean goal achievement in the transdermal oxybutynin and placebo groups (41.9% (SD 31.3) vs 32.2% (SD 27.3), P= 0.203). Transdermal oxybutynin was associated with ...Continue Reading

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Citations

Dec 15, 2015·Expert Opinion on Drug Delivery·Katie ScottPriya Padmanabhan
Jan 23, 2016·Expert Opinion on Pharmacotherapy·Helena Burden, Paul Abrams
Apr 8, 2015·Neurourology and Urodynamics·Emmanuel Chartier-KastlerMichael Chancellor
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Feb 1, 2011·International Urogynecology Journal·Rufus CartwrightDudley Robinson
Sep 5, 2020·Research and Reports in Urology·Raúl Vozmediano-ChicharroBlanca Madurga-Patuel

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