Patient selection criteria for pilot studies on amelioration of non-neovascular age-related macular degeneration.

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Mitsuyoshi AzumaThomas R Shearer

Abstract

Non-neovascular age-related macular degeneration (AMD) is characterized by accumulation of macular drusen, changes in pigmentation of the retinal pigment epithelium, and geographic atrophy. The purposes of this study were to (1) measure the rate of progression of non-neovascular AMD and (2) from the rate data, to propose patient selection criteria for testing drugs to prevent progression of non-neovascular AMD. Medical charts were searched for all AMD billing codes, consecutively reviewed, and 51 patients with a median age of 76 years were mined for severity of AMD using a standardized worsening scale from 0 to 6, visual acuity (VA, Snellen), medications or procedures to treat eye diseases, date of eye examinations, age, and sex. Individual eyes, excluding those with cataract, were grouped and compared. Using all grades, VA (logMAR) was positively correlated with AMD scores (P < 0.0001, n = 66). The median length of time to progress from AMD grade 3 or 4 to the next grade was 1.0 (n = 14) and 1.7 years (n = 7), respectively. Statistical analyses predicted that drug-treated and nontreated groups, each containing 409 grade 3 and 4 AMD eyes, could detect 50% drug inhibition (P = 0.05) in a 2-year trial. VA measurements and structu...Continue Reading

References

Nov 23, 2005·PLoS Medicine·Kristinn P MagnussonJeffrey R Gulcher
Nov 15, 2006·Annals of Medicine·Karen M GehrsGregory S Hageman
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Yogita KananMuayyad R Al-Ubaidi
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Karl G CsakyFrederick L Ferris
Mar 20, 2008·Survey of Ophthalmology·M Azuma, T R Shearer
Oct 28, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hong MaMitsuyoshi Azuma

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