Patient Selection for Ductal Carcinoma In Situ Observation Trials: Are the Lesions Truly Low Risk?

AJR. American Journal of Roentgenology
Gitanjali V PatelRichard Ha

Abstract

The purpose of this article is to report on a study conducted to determine whether the lesions in patients with what is deemed to be low-risk ductal carcinoma in situ (DCIS) selected for two large clinical trials are in fact low-risk lesions. A retrospective review was conducted to determine whether the eligibility criteria of the two trials are predictive that DCIS is low risk. More than 20% of lesions are upgraded to invasive carcinoma in patients with low-risk DCIS as defined in two large clinical trials. More accurate methods are needed to determine whether patients with a diagnosis of low-grade DCIS can be treated less aggressively.

References

Oct 20, 2010·Journal of the National Cancer Institute. Monographs·C CorreaS Darby
Aug 25, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Adele FrancisDaniel Rea

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Citations

Apr 25, 2019·International Journal of Cancer. Journal International Du Cancer·Mieke R Van BockstalCarolien H M van Deurzen
Sep 11, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stuart J Schnitt
Jun 7, 2021·Japanese Journal of Clinical Oncology·Naoko IwamotoTomoyuki Aruga
Sep 22, 2021·Current Opinion in Obstetrics & Gynecology·Farnaz HajiMaggie L DiNome

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Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

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