Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children

Journal of Virology
Florence BuseyneYves Rivière

Abstract

We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24gag QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.

References

Mar 9, 1995·Nature·D L RobertsonB H Hahn
Jan 1, 1997·Immunology Today·J L HeeneyS Zolla-Pazner
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G FerrariK J Weinhold
Jun 25, 1998·Science·N L Letvin
Jul 7, 1998·The Journal of Experimental Medicine·D H BuschE G Pamer
Oct 3, 1999·Vaccine·M Klein
Apr 15, 2000·Science·D L RobertsonB Korber

❮ Previous
Next ❯

Citations

Apr 26, 2005·Journal of Immunological Methods·Florence BuseyneYves Rivière
Sep 18, 2016·Protein & Cell·Xiaolong LiJia-Huai Wang
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·W A ChariniN L Letvin
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrianus C M BoonGuus F Rimmelzwaan
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre BoissonnasBehazine Combadière
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Ross LopesMala K Maini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.