Patient specific identification of the cardiac driver function in a cardiovascular system model

Computer Methods and Programs in Biomedicine
C E HannJ Geoffrey Chase

Abstract

The cardiac muscle activation or driver function, is a major determinant of cardiovascular dynamics, and is often approximated by the ratio of the left ventricle pressure to the left ventricle volume. In an intensive care unit, the left ventricle pressure is usually never measured, and the left ventricle volume is only measured occasionally by echocardiography, so is not available real-time. This paper develops a method for identifying the driver function based on correlates with geometrical features in the aortic pressure waveform. The method is included in an overall cardiovascular modelling approach, and is clinically validated on a porcine model of pulmonary embolism. For validation a comparison is done between the optimized parameters for a baseline model, which uses the direct measurements of the left ventricle pressure and volume, and the optimized parameters from the approximated driver function. The parameters do not significantly change between the two approaches thus showing that the patient specific approach to identifying the driver function is valid, and has potential clinically.

References

Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R Mukkamala, R J Cohen
Nov 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ramakrishna MukkamalaRichard J Cohen
Mar 24, 2004·Medical Engineering & Physics·Bram W SmithGraeme Wake
Feb 19, 2005·European Journal of Heart Failure·Kenneth Dickstein
Mar 12, 2005·The Japanese Journal of Physiology·Eun Bo ShimChan Hyun Youn
Jul 26, 2005·Computer Methods and Programs in Biomedicine·C E HannG M Shaw
May 5, 2007·Computer Methods and Programs in Biomedicine·C StarfingerG M Shaw
Mar 31, 2009·Computer Methods and Programs in Biomedicine·Ashwath SundaresanGeoffrey M Shaw

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Citations

Dec 29, 2015·Journal of Biomechanics·Sanjay PantUNKNOWN for Modeling of Congenital Hearts Alliance (MOCHA) Investigators
Apr 16, 2013·Computational and Mathematical Methods in Medicine·James A RevieThomas Desaive
Apr 14, 2015·Mathematical Biosciences·Antoine PironetPierre C Dauby
Jan 21, 2014·Computer Methods and Programs in Biomedicine·Haydar ÖzkanAli Fuat Boz
Dec 1, 2011·Computer Methods and Programs in Biomedicine·James A RevieThomas Desaive
Sep 5, 2012·The Journal of Thoracic and Cardiovascular Surgery·Koichi SughimotoHao Liu
Feb 6, 2017·Computer Methods and Programs in Biomedicine·Antoine PironetThomas Desaive
May 16, 2017·Journal of Biomaterials Science. Polymer Edition·Ceren Türkcan KayhanAdil Denizli
Jan 13, 2017·Journal of the Royal Society, Interface·Sanjay PantIrene E Vignon-Clementel
Sep 27, 2019·Medical Engineering & Physics·D Rodney HoseFrans N van de Vosse

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