Patient-specific image-based computer simulation for theprediction of valve morphology and calcium displacement after TAVI with the Medtronic CoreValve and the Edwards SAPIEN valve

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Carl J SchultzPeter P T de Jaegere

Abstract

Our aim was to validate patient-specific software integrating baseline anatomy and biomechanical properties of both the aortic root and valve for the prediction of valve morphology and aortic leaflet calcium displacement after TAVI. Finite element computer modelling was performed in 39 patients treated with a Medtronic CoreValve System (MCS; n=33) or an Edwards SAPIEN XT (ESV; n=6). Quantitative axial frame morphology at inflow (MCS, ESV) and nadir, coaptation and commissures (MCS) was compared between multislice computed tomography (MSCT) post TAVI and a computer model as well as displacement of the aortic leaflet calcifications, quantified by the distance between the coronary ostium and the closest calcium nodule. Bland-Altman analysis revealed a strong correlation between the observed (MSCT) and predicted frame dimensions, although small differences were detected for, e.g., Dmin at the inflow (mean±SD MSCT vs. 21.6±2.4 mm vs. 22.0±2.4 mm; difference±SD: -0.4±1.3 mm, p<0.05) and Dmax (25.6±2.7 mm vs. 26.2±2.7 mm; difference±SD: -0.6±1.0 mm, p<0.01). The observed and predicted calcium displacements were highly correlated for the left and right coronary ostia (R2=0.67 and R2=0.71, respectively p<0.001). Dedicated software allow...Continue Reading

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Citations

Mar 12, 2016·JACC. Cardiovascular Interventions·Peter de JaegerePeter Mortier
May 14, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Elchanan Bruckheimer, Carmel Rotschild
Apr 15, 2016·European Heart Journal·Mohammad AbdelghaniPatrick W Serruys
Mar 9, 2017·Expert Review of Cardiovascular Therapy·Hzr McConkeyS Redwood
Sep 7, 2018·International Journal for Numerical Methods in Biomedical Engineering·Mathias PeirlinckMatthieu De Beule
Oct 16, 2018·Expert Review of Medical Devices·Oren M RotmanDanny Bluestein
Nov 22, 2018·Biomechanics and Modeling in Mechanobiology·Matteo BianchiDanny Bluestein
Mar 18, 2017·Echo Research and Practice·Caroline BleakleyMark Monaghan
Nov 22, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jorn BrouwerMartin J Swaans
Oct 9, 2019·Circulation. Cardiovascular Imaging·Cameron DowlingStephen J Brecker
Aug 12, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·P de JaegereJ Baan
Jun 15, 2019·Cardiovascular Engineering and Technology·Giorgia RocatelloPeter Mortier
Nov 21, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marco BarbantiBernard D Prendergast
Nov 27, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·N El FaquirP P de Jaegere
Aug 19, 2017·Biomechanics and Modeling in Mechanobiology·Mathias PeirlinckMatthieu De Beule
Oct 21, 2019·JACC. Cardiovascular Interventions·Cameron DowlingStephen J Brecker
Feb 14, 2021·Trends in Cardiovascular Medicine·Joana Maria RibeiroPeter Pt de Jaegere
Jul 22, 2017·Medical Engineering & Physics·Alice FinotelloFerdinando Auricchio
Jul 20, 2020·JACC. Cardiovascular Interventions·Pascal Thériault-LauzierNicoló Piazza
Jul 20, 2020·JACC. Cardiovascular Interventions·Nahid El FaquirPeter de Jaegere
May 22, 2018·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ramón Rodríguez-OlivaresNicolas M Van Mieghem
Jun 16, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Dong QiuAli N Azadani
Dec 31, 2019·Clinical Radiology·A Yucel-FinnJ R Weir-McCall
Nov 20, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Patrick W SerruysOsama Soliman

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