Patient-specific phosphorus mobilization clearance during nocturnal and short daily hemodialysis

Hemodialysis International
Baris U AgarJohn K Leypoldt

Abstract

The kinetics of plasma phosphorus during different hemodialysis (HD) modalities are incompletely understood. We recently demonstrated that a pseudo one-compartment kinetic model including phosphorus mobilization from various body compartments into extracellular fluids can describe intradialytic and postdialytic rebound kinetics of plasma phosphorus during conventional and short 2-hour HD treatments. In this model, individual patient differences in phosphorus kinetics were characterized by a single parameter, the phosphorus mobilization clearance (K(M)). In this report we determined K(M) in patients treated by in-center nocturnal HD (ICNHD) and short daily HD (SDHD) with low dialyzer phosphate clearance. In the ICNHD study, eight patients underwent 8-hour HD treatments where intradialytic and postdialytic plasma samples were collected; K(M) values were determined by nonlinear regression of plasma concentration as a function of time. In the SDHD study, five patients were studied during 28 treatments for approximately 3 hours. Here, K(M) was calculated using only predialytic and postdialytic plasma phosphorus concentrations. Dialyzer phosphate clearances were 134 ± 20 (mean ± SD) and 95 ± 16 mL/min during ICNHD and SDHD, respectiv...Continue Reading

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Citations

May 30, 2013·Kidney International·John K LeypoldtBruce F Culleton
May 23, 2015·Artificial Organs·Malgorzata DebowskaWojciech Zaluska
Oct 17, 2012·Hemodialysis International·John K LeypoldtBruce F Culleton
Aug 6, 2014·Hemodialysis International·Baris U AgarJohn K Leypoldt
Mar 15, 2013·Blood Purification·John K LeypoldtBruce F Culleton
Dec 15, 2015·The International Journal of Artificial Organs·Sisse H LaursenOle K Hejlesen
Nov 19, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·František ŠváraOndřej Pecha
Feb 27, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John K LeypoldtBruce F Culleton
Mar 7, 2015·The International Journal of Artificial Organs·Masatomo YashiroRumi Sakai

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