Patient-specific treatment planning of electrochemotherapy: procedure design and possible pitfalls

Bioelectrochemistry
D PavlihaDamijan Miklavcic

Abstract

Electrochemotherapy uses electroporation for enhancing chemotherapy. Electrochemotherapy can be performed using standard operating procedures with predefined electrode geometries, or using patient-specific treatment planning to predict electroporation. The latter relies on realistic computer models to provide optimal results (i.e. electric field distribution as well as electrodes' position and number) and is suitable for treatment of deep-seated tumors. Since treatment planning for deep-seated tumors has been used in radiotherapy, we expose parallelisms with radiotherapy in order to establish the procedure for electrochemotherapy of deep-seated tumors. We partitioned electrochemotherapy in the following phases: the mathematical model of electroporation, treatment planning, set-up verification, treatment delivery and monitoring, and response assessment. We developed a conceptual treatment planning software that incorporates mathematical models of electroporation. Preprocessing and segmentation of the patient's medical images are performed, and a 3D model is constructed which allows placement of electrodes and implementation of the mathematical model of electroporation. We demonstrated the feasibility of electrochemotherapy of de...Continue Reading

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Citations

Aug 28, 2012·The Journal of Membrane Biology·Damijan Miklavčič
Nov 28, 2012·Medical & Biological Engineering & Computing·D MiklavčičT Jarm
Feb 26, 2013·Biomedical Engineering Online·Selma CorovicDamijan Miklavcic
Mar 2, 2013·Radiology and Oncology·Barbara MaliTomaz Jarm
Mar 14, 2014·Biomedical Engineering Online·Damijan MiklavčičGregor Serša
Oct 29, 2015·Bioelectromagnetics·Azadeh PeymanDamijan Miklavčič
Jun 20, 2013·The Journal of Membrane Biology·Denis PavlihaDamijan Miklavčič
May 2, 2014·Journal of Surgical Oncology·Ibrahim EdhemovicGregor Sersa
Sep 7, 2013·Journal of Biomechanical Engineering·Christopher B ArenaRafael V Davalos
Feb 12, 2017·Journal of Surgical Oncology·Eduardo L LatoucheRobert C G Martin
Jul 31, 2018·Journal of Healthcare Engineering·José Alvim BerkenbrockDaniela Ota Hisayasu Suzuki
Jul 11, 2018·Technology in Cancer Research & Treatment·Ute ProbstPhilipp Wiggermann
Sep 23, 2020·Artificial Organs·Maurício Martins TaquesDaniela Ota Hisayasu Suzuki
May 11, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ibrahim EdhemovicGregor Sersa

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