Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury.

Frontiers in Neurology
Andrei IrimiaJohn D Van Horn

Abstract

Available approaches to the investigation of traumatic brain injury (TBI) are frequently hampered, to some extent, by the unsatisfactory abilities of existing methodologies to efficiently define and represent affected structural connectivity and functional mechanisms underlying TBI-related pathology. In this paper, we describe a patient-tailored framework which allows mapping and characterization of TBI-related structural damage to the brain via multimodal neuroimaging and personalized connectomics. Specifically, we introduce a graphically driven approach for the assessment of trauma-related atrophy of white matter connections between cortical structures, with relevance to the quantification of TBI chronic case evolution. This approach allows one to inform the formulation of graphical neurophysiological and neuropsychological TBI profiles based on the particular structural deficits of the affected patient. In addition, it allows one to relate the findings supplied by our workflow to the existing body of research that focuses on the functional roles of the cortical structures being targeted. A graphical means for representing patient TBI status is relevant to the emerging field of personalized medicine and to the investigation o...Continue Reading

Citations

May 23, 2012·PloS One·John Darrell Van HornArthur W Toga
Feb 12, 2014·Nature Reviews. Neurology·David J SharpRobert Leech
Feb 26, 2016·NeuroImage. Clinical·Jace B KingDeborah A Yurgelun-Todd
Jun 13, 2015·Brain Injury : [BI]·Philip J A DeanAnnette Sterr
Dec 8, 2015·NeuroImage. Clinical·Stavros I DimitriadisAndrew C Papanicolaou
May 10, 2013·Journal of Neuropathology and Experimental Neurology·Brian L EdlowRebecca D Folkerth
Dec 21, 2014·Microscopy·Shinsuke ShibataHideyuki Okano
Nov 4, 2015·Frontiers in Neuroscience·Philip P Foster
Aug 22, 2013·IEEE Transactions on Bio-medical Engineering·Yifei LouAllen R Tannenbaum
Jun 12, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrei IrimiaJohn D Van Horn
May 11, 2013·NeuroImage·Daniel S MarguliesKrzysztof J Gorgolewski
Dec 28, 2012·NeuroImage·Julia P OwenPratik Mukherjee
May 23, 2014·Frontiers in Neuroinformatics·Martin LuessiAggelos K Katsaggelos
Nov 27, 2014·Frontiers in Neuroinformatics·Carinna M Torgerson, John D Van Horn
Oct 24, 2014·Human Brain Mapping·Carinna M TorgersonJohn Darrell Van Horn
Feb 19, 2016·Journal of the International Neuropsychological Society : JINS·Jasmeet P HayesMieke Verfaellie
Oct 9, 2018·Network Neuroscience·Johnson J G KeirizAngus G Forbes

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