Patients Admitted to Three Spanish Intensive Care Units for Poisoning: Type of Poisoning, Mortality, and Functioning of Prognostic Scores Commonly Used

BioMed Research International
María Esther Banderas-BravoRicardo Rivera-Fernández

Abstract

Objectives . To evaluate the gravity and mortality of those patients admitted to the intensive care unit for poisoning. Also, the applicability and predicted capacity of prognostic scales most frequently used in ICU must be evaluated.Methods. Multicentre study between 2008 and 2013 on all patients admitted for poisoning.Results. The results are from 119 patients. The causes of poisoning were medication, 92 patients (77.3%), caustics, 11 (9.2%), and alcohol, 20 (16,8%). 78.3% attempted suicides. Mean age was 44.42 ± 13.85 years. 72.5% had a Glasgow Coma Scale (GCS) ≤8 points. The ICU mortality was 5.9% and the hospital mortality was 6.7%. The mortality from caustic poisoning was 54.5%, and it was 1.9% for noncaustic poisoning (p< 0.001). After adjusting for SAPS-3 (OR: 1.19 (1.02-1.39)) the mortality of patients who had ingested caustics was far higher than the rest (OR: 560.34 (11.64-26973.83)). There was considerable discrepancy between mortality predicted by SAPS-3 (26.8%) and observed (6.7%) (Hosmer-Lemeshow test:H= 35.10;p< 0.001). The APACHE-II (7,57%) and APACHE-III (8,15%) were no discrepancies.Conclusions. Admission to ICU for poisoning is rare in our country. Medication is the most frequent cause, but mortality of caus...Continue Reading

References

Dec 1, 1992·Toxicology Letters·S NoguéE Civeira
Jan 1, 1982·American Journal of Epidemiology·S Lemeshow, D W Hosmer
Jul 29, 1998·Intensive Care Medicine·Ricardo Rivera-FernándezW A Knaus
Aug 28, 2004·Gastrointestinal Endoscopy·Jan-Werner PoleyPeter D Siersema
Oct 15, 2005·Acta Anaesthesiologica Scandinavica·M ColmeneroE Fernández Mondéjar
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Jean Roger Le GallDaniel Villers
Feb 14, 2006·Revista española de salud pública·Alfonso Appellániz, Ricardo Manzanaro
Aug 4, 2006·The Laryngoscope·Carlos Arévalo-SilvaMenachem Gross
Jun 6, 2007·Journal of Critical Care·Ricardo Rivera-FernándezDinis Reis Miranda
Mar 12, 2008·Critical Care : the Official Journal of the Critical Care Forum·Virginia Chamorro-MarínEnrique Fernández-Mondéjar
Mar 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·M García-DelgadoEnrique Fernández-Mondéjar
Jul 11, 2013·World Journal of Gastroenterology : WJG·Sandro Contini, Carmelo Scarpignato
Sep 24, 2013·Medicina intensiva·C López-CalerRicardo Rivera-Fernández
Mar 4, 2014·Critical Care Medicine·Raya BrandenburgDylan W de Lange
May 14, 2014·Acta Anaesthesiologica Scandinavica·O A HaalandK A Johansson

Citations

Mar 13, 2018·Basic & Clinical Pharmacology & Toxicology·Esmaeil FarzanehOmid Mehrpour
Dec 7, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Selda KaragozOya Hergunsel
Jan 20, 2021·Critical Care : the Official Journal of the Critical Care Forum·Kap Su HanSung Woo Lee
Sep 29, 2020·Drug Metabolism and Personalized Therapy·Alireza AmirabadizadehOmid Mehrpour

Related Concepts

Intensive Care Unit
Poisoning
Retrospective Studies
Suicide
Apache III
Angiotensin II
Glasgow Coma Scale
Hispanics
Hospital Admission
Evaluation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.