Patients' awareness of extrapyramidal reactions to neuroleptic drugs: possible evidence for the role of catecholamines in perception

Psychiatry Research
R FreedmanP J Schwab


The awareness of extrapyramidal reactions during initiation of neuroleptic treatment was studied in 14 patients. Only one patient spontaneously identified the presence of dystonia. The other 13, including 3 who had experienced extrapyramidal reactions during previous hospitalizations, did not fully identify the presence of symptoms, although several had vague discomfort. There was marked variability in acknowledgement of symptoms in response to prompting by staff members. The findings are similar to reports of agnosia for hemiparesis after parietal lobe injury and also to descriptions of agnosia in animals caused by destruction of dopaminergic neurons. Since extrapyramidal reactions represent blockade of dopaminergic neurotransmission, patients' inability to perceive the reactions may represent evidence for catecholaminergic modulation of sensory perception.


Oct 31, 2003·The New England Journal of Medicine·R Freedman
Apr 26, 2017·Nature Communications·Emily A PartridgeAlan W Flake
Jun 1, 1983·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·T P Hogan, A G Awad


Feb 1, 1978·The American Journal of Psychiatry·A Carlsson
Jun 23, 1977·The New England Journal of Medicine·N Geschwind
Jul 1, 1974·Archives of General Psychiatry·T Van Putten
Jan 1, 1974·Journal of Psychiatric Research·U Ungerstedt, T Ljungberg
Sep 1, 1972·The American Journal of Psychiatry·D E Raskin

Related Concepts

Antipsychotic Effect
Entire Parietal Lobe
Catecholamines Measurement
Synaptic Transmission
Transcription Initiation
Sensory Discomfort
Lenticulostriate Disorders

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here