Patients cured from craniopharyngioma or nonfunctioning pituitary macroadenoma (NFMA) suffer similarly from increased daytime somnolence despite normal sleep patterns compared to healthy controls

Clinical Endocrinology
A A van der KlaauwJ A Romijn

Abstract

Adults patients previously treated for craniopharyngioma have increased general and physical fatigue compared to healthy controls. This could be related to disturbed sleep patterns. The aim of this study was to compare sleepiness and sleep patterns in those patients to healthy controls and to patients treated for nonfunctioning macroadenomas (NFMA) of the pituitary. Case-control study. Sleepiness and sleep patterns were assessed in 27 adult patients [14 men, 8 patients diagnosed at childhood age, mean age of 53 years (range 27-80 year)] after long-term follow-up and compared to 50 healthy controls and 38 age-, gender- and BMI-matched patients with NFMA. We used two validated questionnaires for sleep parameters (Epworth sleepiness score and Münchener Chronotype Questionnaire). Sleep patterns (onset, sleep timing, duration and rise time) were not statistically different between the three groups. However, daytime sleepiness scores were increased in patients treated for craniopharyngioma compared to healthy controls, but not different from patients with NFMA. Thirty-three percent of patients with craniopharyngiomas had ESS scores above 10 compared to 8% of healthy controls (P = 0.005), indicating severe daytime hypersomnolence. Nei...Continue Reading

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Citations

Sep 11, 2012·Pituitary·Eva Marie ErfurthSigridur Bara Fjalldal
Apr 1, 2014·European Journal of Endocrinology·Line PickeringMarianne Klose
Jul 12, 2012·Journal of Sleep Research·Lisa M VerberneAntoinette Y N Schouten-Van Meeteren
Mar 21, 2015·European Journal of Endocrinology·Sarah M LeistnerCaroline Sievers
Jun 4, 2016·Nature Reviews. Endocrinology·Johannes A Romijn
Mar 25, 2010·The Journal of Clinical Endocrinology and Metabolism·Clodagh S O'GormanJill Hamilton
Apr 9, 2019·Endocrine-related Cancer·Anna AngelousiGeorge P Chrousos
Jun 3, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Johannes A Romijn
Dec 17, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Eva Marie Erfurth
Apr 25, 2012·Journal of Neuro-oncology·Peter E ManleyNicole J Ullrich
Jul 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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