Patients electing to have PET rather than surgery for operable breast cancer are a high risk of treatment failure

Breast Cancer Research and Treatment
Robert ThomasHenry Cain

Abstract

Primary endocrine therapy (PET) is a treatment option for elderly patients with ER-positive breast cancer enabling frail patients to avoid surgery. As a long-term treatment option, it has been shown to be inferior to surgery in controlling local disease. Decision-making in these patients is crucial in avoiding treatment failure. We examined the influence of decision-making on outcomes of PET failure as a secondary analysis as part of a large observational study. Consecutive patients treated with PET between 2005 and 2015 for operable breast cancers were included in a retrospective observational study in 3 breast centres in the North-East. Treatment decision processes were examined by case note review and outcomes of treatment success or failure recorded. 488 patients were included with mean follow-up of 31 months. Overall 63 (12%) experienced treatment failure. 227 (46.6%) were given a choice between surgery and PET at diagnosis. Logistic regression identified older age [OR 0.94 (0.91-0.96) p < 0.001] and reduced mobility [OR 0.6 (0.37-0.97) p 0.036] to be less likely offered surgery. Those offered surgery were more likely to experience treatment failure with PET [SHR 1.78 (1.05-3.02) p 0.033]. Despite a low failure rate in our...Continue Reading

References

Jan 27, 2006·The Cochrane Database of Systematic Reviews·D HindM W Reed
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martine Extermann, Arti Hurria
Dec 20, 2008·Journal of the American Geriatrics Society·Lona ModyStephanie Studenski
Feb 9, 2012·American Journal of Clinical Oncology·Kathryn E WeaverGretchen Kimmick
Jul 11, 2013·Annals of the Royal College of Surgeons of England·S Wylie, D Ravichandran
Apr 8, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J L MorganL Wyld
Feb 19, 2015·The British Journal of Surgery·R JamesR D Macmillan

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