Patients exposed to Mycobacterium tuberculosis infection with a prominent IgE response

Archives of Medical Research
Zaida AraujoJacobus H de Waard

Abstract

Even though it has been reported that chronic immune activation associated with intestinal helminthic infections results in a predominant IgE response, specific IgE antibodies that are also interleukin 4 (IL-4) dependent have been reported in tuberculosis patients; however, this fact has not been widely reported. This study was aimed at investigating the levels of circulating IgE in Warao (an indigenous population) of the Orinoco river delta, an area isolated from contact with the tubercle bacillus for millennia until the mid-1960s as compared to Creole (nonindigenous population). A total of 294 individuals were studied, 161 Warao and 136 Creole. Patient group was comprised of 86 Warao patients (WP) and 60 Creole patients (CP). Control group was comprised of 75 Warao controls (WC) and 76 Creole controls (CC). Total serum IgE and IgE and IgG(4) reactivities to M. tuberculosis antigens were measured by an enzyme-linked immunosorbent assay (ELISA). Levels of total serum IgE were significantly elevated in WP (13002.0 ± 11200.0 IU/mL) and WC (2763.5 ± 2596.2 IU/mL) than in CP (385.9 ± 155.1 IU/mL) and CC (356.6 ± 157.5 IU/mL) (p <0.0001). Anti-PPD and anti-H37Rv IgE were significantly higher in WP (0.240 ± 0.145 and 0.230 ± 0.155) t...Continue Reading

References

Jun 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·T ArnadottirH T Waaler
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·A O SousaH L David
Mar 5, 1998·The New England Journal of Medicine·R BellamyA V Hill
Jun 22, 1999·Lancet·J F AdamsA D Beyers
Sep 9, 2000·The Journal of Infectious Diseases·P J CooperT B Nutman
Sep 30, 2000·Clinical and Experimental Immunology·T OhruiH Sasaki
Mar 24, 2006·Tropical Medicine & International Health : TM & IH·Daniel EliasSven Britton

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Citations

Jun 3, 2014·Parasites & Vectors·Andargachew MuluDaniel Elias
Jan 6, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yiling ZhangLiqiang Feng
Jun 1, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Zaida AraujoJosé Antonio Enciso-Moreno

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