Abstract
The objective of this study was to quantify patients' preferences related to benefits and risks of antipsychotic treatments for schizophrenia and to assess the relative importance of treatment attributes and adherence. Treatment-related preferences among U.S. residents with a self-reported physician diagnosis of schizophrenia were assessed via a discrete-choice experiment. Patients chose between competing hypothetical scenarios characterized by improvements in positive symptoms, negative symptoms, and social functioning; incidence of weight gain, extrapyramidal symptoms (EPS), hyperprolactinemia, and hyperglycemia; and medication formulation. Preferences were estimated by using a random-parameters logit model, and the impact of adherence was estimated with conditional logit models. The final sample consisted of 271 patients. Complete improvement in positive symptoms was the most preferred outcome (relative importance score of 10.0), followed by elimination of hyperglycemia (3.6, 95% confidence interval [CI]=2.6-4.6), improvement in negative symptoms (3.0, CI=1.6-4.3), reduced weight gain (2.6, CI=1.2-4.0), avoidance of hyperprolactinemia (1.7, CI=.9-2.6), improved social functioning (1.5, CI=.4-2.5), and avoidance of EPS (1.0, ...Continue Reading
Citations
Apr 14, 2016·British Journal of Clinical Pharmacology·Emily A F HolmesDyfrig A Hughes
Oct 12, 2017·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Victoria Alguera-LaraDavid Castle
Apr 27, 2018·Journal of Comparative Effectiveness Research·Daisy Ng-MakAntony Loebel
Nov 6, 2018·PharmacoEconomics·Vikas SoekhaiCaroline M Vass
Jun 4, 2020·Neuropsychopharmacology Reports·Kie TakahashiHiroyuki Uchida
Sep 26, 2017·Current Medical Research and Opinion·Kathleen BeusterienJohn F P Bridges
May 26, 2017·PharmacoEconomics·Caroline M Vass, Katherine Payne
Aug 25, 2017·Early Intervention in Psychiatry·Mackenzie BeckerRobert B Zipursky
Jun 27, 2019·Journal of Mental Health·Vivien YeoDavid J Castle
Sep 7, 2019·Therapeutic Advances in Drug Safety·Juhaeri Juhaeri
Dec 9, 2020·Pharmacopsychiatry·Gerhard GründerStefan Leucht
Jan 13, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Nichole GoodsmithAlexander S Young
Nov 6, 2020·Patient Preference and Adherence·Michael J DoaneDawn I Velligan
Aug 22, 2021·Health & Social Care in the Community·Claire HutchinsonJulie Ratcliffe